ReviewFEMS microbiology reviews2018
Metals in fungal virulence.
Review in FEMS microbiology reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Matter of Metals: Copper but Not Cadmium Affects the Microbial Alpha-Diversity of Soils and Sediments - a Meta-analysis.Microbial ecology · 2023Pooled it
- Seasonal Shifts in Metal-Associated Fungal Community Dynamics and Functional Potentials in Chinese Coastal Sediments.Environmental microbiology · 2026Article
- A Therapeutic Copper Hydrogel for Seborrheic Dermatitis: From Fungal Eradication to Skin Lesion Repair.Advanced healthcare materials · 2026Article
- Nitroxoline exerts potent anti-Antimicrobial agents and chemotherapy · 2026Article
- TheJournal of fungi (Basel, Switzerland) · 2026Article
- Nematode-trapping devices of Arthrobotrys oligospora is an iron storage system mediated by elevated temperatures.FEMS microbiology ecology · 2026Article
- Determination of Potential Inhibitors againstCurrent pharmaceutical design · 2026Review
- A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism inmSystems · 2025Article
- A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistantAntimicrobial agents and chemotherapy · 2025Article
- In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species.Mycoses · 2025Article
- Co-Expression Network Analysis Suggests PacC Transcriptional Factor Involved inJournal of fungi (Basel, Switzerland) · 2025Article
- Manganese-modulated proteome and phosphoproteome dataset in the opportunistic yeastData in brief · 2025Article
- A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone onBiofilm · 2025Article
- SidF, a dual substrate N5-acetyl-N5-hydroxy-L-ornithine transacetylase involved inJournal of structural biology: X · 2025Article
- Essential role of hepcidin in host resistance to disseminated candidiasis.Cell reports · 2025Article
- Deletion ofmSphere · 2025Article
- Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025Review
- The Ferroxidase-Permease System for Transport of Iron Across Membranes: From Yeast to Humans.International journal of molecular sciences · 2025Review
- The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses inFrontiers in cell and developmental biology · 2025Review
- MRI differentiation of CNS fungal infections: correlating imaging features with microbiological and histopathological findings.Neuroradiology · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metals are essential for life, and they play a central role in the struggle between infecting microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the 'nutritional immunity', in which metals are actively restricted (or, in an extended definition of the term, locally enriched) by the host to hinder microbial growth and virulence. Consequently, fungi have evolved often complex regulatory networks, uptake and detoxification systems for essential metals such as iron, zinc, copper, nickel and manganese. These systems often differ fundamentally from their bacterial counterparts, but even within the fungal pathogens we can find common and unique solutions to maintain metal homeostasis. Thus, we here compare the common and species-specific mechanisms used for different metals among different fungal species-focusing on important human pathogens such as Candida albicans, Aspergillus fumigatus or Cryptococcus neoformans, but also looking at model fungi such as Saccharomyces cerevisiae or A. nidulans as well-studied examples for the underlying principles. These direct comparisons of our current knowledge reveal that we have a good understanding how model fungal pathogens take up iron or zinc, but that much is still to learn about other metals and specific adaptations of individual species-not the least to exploit this knowledge for new antifungal strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.