ArticleJournal of experimental botany2017
ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Poplar miR1447 Is a Negative Regulator of Disease Resistance Through the SA-Dependent Pathway.Plant biotechnology journal · 2026Article
- Genome-Wide Identification Analysis of the MAPKKK Gene Family in Cotton and Its Role in Development and Stress Response.International journal of molecular sciences · 2026Article
- Ghr-miR166b-GhHB14 Pair With GhDLO1 Partner Mediates Cotton Plant Defence Against Verticillium dahliae.Molecular plant pathology · 2025Article
- Function of floral fragrance-related microRNAs and their targets in Hedychium coronarium.BMC genomics · 2025Article
- MicroRNA gatekeepers: Orchestrating rhizospheric dynamics.Journal of integrative plant biology · 2025Review
- The cotton MYB33 gene is a hub gene regulating the trade-off between plant growth and defense in Verticillium dahliae infection.Journal of advanced research · 2024Article
- Review
- Osa-miR11117 TargetsInternational journal of molecular sciences · 2023Article
- Identification of miRNAs Involving Potato-Plants (Basel, Switzerland) · 2023Article
- Physiological and Molecular Characteristics of Southern Leaf Blight Resistance in Sweet Corn Inbred Lines.International journal of molecular sciences · 2022Article
- The Protein Phosphatase GhAP2C1 Interacts Together with GhMPK4 to Synergistically Regulate the Immune Response toInternational journal of molecular sciences · 2022Article
- Identification of miRNA-Target Gene Pairs Responsive toBiomolecules · 2021Article
- GhWRKY21 regulates ABA-mediated drought tolerance by fine-tuning the expression of GhHAB in cotton.Plant cell reports · 2021Article
- Weighted Gene Co-Expression Network Analysis Reveals Hub Genes Contributing to Fuzz Development inGenes · 2021Article
- MicroRNAs: Potential Targets for Developing Stress-Tolerant Crops.Life (Basel, Switzerland) · 2021Review
- Understanding the molecular mechanisms of trade-offs between plant growth and immunity.Science China. Life sciences · 2021Review
- MicroRNA Techniques: Valuable Tools for Agronomic Trait Analyses and Breeding in Rice.Frontiers in plant science · 2021Review
- Analysis of miRNA expression associated with the Lr46 gene responsible for APR resistance in wheat (Triticum aestivum L.).Journal of applied genetics · 2020Article
- Elucidating micro RNAs role in different plant-pathogen interactions.Molecular biology reports · 2020Review
- Scaffold protein GhMORG1 enhances the resistance of cotton to Fusarium oxysporum by facilitating the MKK6-MPK4 cascade.Plant biotechnology journal · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium wilt is a major biotic stress affecting the productivity of cotton (Gossypium hirsutum). Although mitogen-activated protein kinase (MAPK) cascades play critical roles in plant disease resistance, their intricate regulation under fungal stress remains unclear, especially with regards to microRNA-mediated regulation of MAPK gene expression. In this study, we report that the MAPK kinase gene GhMKK6 and ghr-miR5272a work together in cotton resistance to Fusarium wilt. Silencing GhMKK6 in cotton decreased resistance to F. oxysporum by repressing the expression of known disease-resistance genes. Furthermore, although GhMKK6 played a positive role in disease resistance, excessive GhMKK6 activation caused an excessive hypersensitive response. ghr-miR5272a, a major regulator, prevents this excessive response by regulating GhMKK6 expression. ghr-miR5272a targets the GhMKK6 3'-untranslated region in cotton. Overexpressing miR5272a decreased the expression of GhMKK6 and disease-resistance genes, and increased sensitivity to F. oxysporum, yielding a similar phenotype to GhMKK6-silenced cotton. Overall, these results demonstrate that the ghr-miR5272a-mediated regulation of GhMKK6 expression contributes to the immune response in cotton, and reveal a new feedback loop mechanism in plant disease response.
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