ArticleMolecular biology and evolution2018
Recombination Alters the Dynamics of Adaptation on Standing Variation in Laboratory Yeast Populations.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium.Genome biology and evolution · 2026Article
- Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load.Science (New York, N.Y.) · 2026Article
- Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data.Molecular ecology · 2025Review
- Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved Yeast Populations.Molecular ecology · 2025Article
- Selection Can Favor a Recombination Landscape That Limits Polygenic Adaptation.Molecular biology and evolution · 2025Article
- Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.Molecular systems biology · 2024Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
- The distribution of fitness effects during adaptive walks using a simple genetic network.PLoS genetics · 2024Article
- Article
- Embracing Complexity: Yeast Evolution Experiments Featuring Standing Genetic Variation.Journal of molecular evolution · 2023Review
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations.Molecular biology and evolution · 2022Article
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae.Genetics · 2022Article
- The transcriptomic signature of obligate parthenogenesis.Heredity · 2022Article
- Strong selection and high mutation supply characterize experimental Chlorovirus evolution.Virus evolution · 2022Article
- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- The genetic basis of differential autodiploidization in evolving yeast populations.G3 (Bethesda, Md.) · 2021Article
- Resampling the pool of genotypic possibilities: an adaptive function of sexual reproduction.BMC ecology and evolution · 2021Article
- Review
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2 authors.
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Abstract
The rates and selective effects of beneficial mutations, together with population genetic factors such as population size and recombination rate, determine the outcomes of adaptation and the signatures this process leaves in patterns of genetic diversity. Previous experimental studies of microbial evolution have focused primarily on initially clonal populations, finding that adaptation is characterized by new strongly selected beneficial mutations that sweep rapidly to fixation. Here, we study evolution in diverse outcrossed yeast populations, tracking the rate and genetic basis of adaptation over time. We combine time-serial measurements of fitness and allele frequency changes in 18 populations of budding yeast evolved at different outcrossing rates to infer the drivers of adaptation on standing genetic variation. In contrast to initially clonal populations, we find that adaptation is driven by a large number of weakly selected, linked variants. Populations undergoing different rates of outcrossing make use of this selected variation differently: whereas asexual populations evolve via rapid, inefficient, and highly variable fixation of clones, sexual populations adapt continuously by gradually breaking down linkage disequilibrium between selected variants. Our results demonstrate how recombination can sustain adaptation over long timescales by inducing a transition from selection on genotypes to selection on individual alleles, and show how pervasive linked selection can affect evolutionary dynamics.
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