ArticleNucleic acids research2017
Asymmetric cell division requires specific mechanisms for adjusting global transcription.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Global changes in synthesis rates and mRNA stabilities during adaptive responses to cell wall stress in yeast.Scientific reports · 2025Article
- Homeostasis of mRNA concentrations through coupling transcription, export, and degradation.iScience · 2024Article
- A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection.PloS one · 2022Article
- Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration.RNA biology · 2021Article
- Transcription coordinates histone amounts and genome content.Nature communications · 2021Article
- Noise suppression in stochastic genetic circuits using PID controllers.PLoS computational biology · 2021Article
- Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.PLoS genetics · 2021Article
- Eukaryotic RNA Polymerases: The Many Ways to Transcribe a Gene.Frontiers in molecular biosciences · 2021Review
- Modeling homeostasis mechanisms that set the target cell size.Scientific reports · 2020Article
- Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability.RNA biology · 2019Article
- The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4.Nucleic acids research · 2019Article
- Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.Current biology : CB · 2019Article
- Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values inG3 (Bethesda, Md.) · 2019Article
- Cell size control and gene expression homeostasis in single-cells.Current opinion in systems biology · 2018Article
- Ergodicity, hidden bias and the growth rate gain.Physical biology · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.