Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Immediate Antiretroviral Therapy Decreases Mortality Among Patients With High CD4 Counts in China: A Nationwide, Retrospective Cohort Study.
Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Rapid initiation of antiretroviral therapy for people living with HIV.The Cochrane database of systematic reviews · 2019Pooled it
- HIV update for the non-HIV specialist and general physician.Clinical medicine (London, England) · 2026Review
- Resilience and Its Determinants Among Adolescents and Young Adults with Perinatally Acquired HIV Enrolled in a Peer-Led Mentorship Program in India.AIDS and behavior · 2026Article
- Genetic diversity and antiretroviral resistance of human immunodeficiency virus type 1 in Peruvian military personnel during one year of follow-upBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Evolution of death trends and influencing factors of people living with HIV from 2003 to 2025 in Huangshi, China.BMC public health · 2026Article
- Data-driven Modeling of Long-term CD4 Cell Recovery Trajectories Under Modern Antiretroviral Therapy in People Living With HIV.Open forum infectious diseases · 2026Article
- Clinical impact and cost-effectiveness of rapid versus non-rapid antiretroviral therapy initiation in HIV-positive men who have sex with men in China using modelling and 96-week multicenter cohort data.Scientific reports · 2026Article
- Effect of rapid antiretroviral therapy initiation on loss to follow-up, virologic failure, and immunologic failure among people living with HIV under the treat-all policy in China: a retrospective cohort study (2016-2023).Frontiers in medicine · 2026Article
- Immune reconstitution and long-term survival outcomes in LTHIs and TPs living with long-term ART: a propensity score-matched cohort study in Xinjiang, China.Frontiers in public health · 2026Article
- Risk of Mortality Associated with Rapid versus Delayed ART Initiation and Associated Factors Among Late-Presenting People with HIV: An 8-Year Retrospective Analysis in China.Infection and drug resistance · 2026Article
- Longitudinal trends in mortality and its causes among migrant HIV/AIDS patients undergoing antiretroviral therapy compared to their counterparts: a cohort study, 2016-2022.BMC public health · 2025Article
- Rapid Antiretroviral Therapy Initiation Reduces Mortality Among People Living With HIV in Indonesia: A Retrospective Observational Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Observational
- Sickle cell trait, APOL1 risk allele status and chronic kidney disease among ART-experienced adults living with HIV in northern Nigeria.International journal of STD & AIDS · 2025Article
- Universal "Test and Treat" for HIV Had Little Effect on Outcomes, but Missed Clinic Visits Threaten Success of Botswana's National Antiretroviral Treatment Program.AIDS patient care and STDs · 2025Article
- Predictive Factors of ART Follow-Up Loss in HIV Patients (2018-2022): A Retrospective Cohort Study.AIDS and behavior · 2025Article
- HIV/AIDS Mortality Trends in Lang Son, Vietnam: Insights from a Population-Based Mortality Registration from 2005 to 2018.Tropical medicine and infectious disease · 2025Article
- A prospective observational cohort study of HIV infection in Indonesia: baseline characteristics and one-year mortality.BMC infectious diseases · 2025Observational
- The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men.BMC infectious diseases · 2025Article
- The lung microbiome in patients with HIV complicated with community-acquired pneumonia: a cross-sectional pilot study.Current research in microbial sciences · 2025Article
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Abstract
Background: Clinical trials have demonstrated that immediate initiation of antiretroviral therapy (ART) reduces AIDS-related morbidity and mortality. We tested the hypothesis that initiating ART ≤30 days after human immunodeficiency virus (HIV) diagnosis would be associated with reduced mortality among people living with HIV (PLWH) with CD4 counts >500 cells/μL. Methods: PLWH enrolled in the Chinese National HIV Information System between January 2012 and June 2014 with CD4 counts >500 cells/μL were followed for 12 months. Cox proportional hazards model was used to determine hazard ratios (HRs) for PLWH who initiated ART after HIV diagnosis. ART initiation was treated as a time-dependent variable. Results: We enrolled 34581 PLWH with CD4 >500 cells/μL; 1838 (5.3%) initiated ART ≤30 days after diagnosis (immediate ART group), and 19 deaths were observed with a mortality rate of 1.04 per 100 person-years (PY). Fifty-eight deaths were documented among the 5640 PLWH in the delayed ART group with a mortality rate of 2.25 per 100 PY. There were 713 deaths among the 27103 PLWH in the no ART group with a mortality rate of 2.39 per 100 PY. After controlling for potential confounding factors, ART initiation at ≤30 days (adjusted HR, 0.37 [95% confidence interval, .23-.58]) was a statistically significant protective factor. Conclusions: We found that immediate ART is associated with a 63% reduction in overall mortality among PLWH with CD4 counts >500 cells/μL in China, supporting the recommendation to initiate ART immediately following HIV diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.