ArticleGenome biology and evolution2017
The Diversification of Zika Virus: Are There Two Distinct Lineages?
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Article
- Article
- The fetal lineage is susceptible to Zika virus infection within days of fertilization.Development (Cambridge, England) · 2022Article
- Zika M-A Potential Viroporin: Mutational Study and Drug Repurposing.Biomedicines · 2022Article
- Downregulation of transcriptional activity, increased inflammation, and damage in the placenta followingFrontiers in virology (Lausanne, Switzerland) · 2022Article
- Genome-wide diversity of Zika virus: Exploring spatio-temporal dynamics to guide a new nomenclature proposal.Virus evolution · 2022Article
- Discriminating arboviral species.The Journal of general virology · 2021Article
- Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains.Nature communications · 2021Article
- Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity.Biomolecules · 2019Article
- The Rescue and Characterization of Recombinant, Microcephaly-Associated Zika Viruses as Single-Round Infectious Particles.Viruses · 2019Article
- Musashi binding elements in Zika and related Flavivirus 3'UTRs: A comparative study in silico.Scientific reports · 2019Article
- Mucocutaneous Features of Zika-a Review.Current infectious disease reports · 2019Review
- Minimum InDel pattern analysis of the Zika virus.BMC genomics · 2018Article
- Article
- Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) has caused explosive epidemics in the Pacific and the Americas, posing a serious threat to public health. Conventional opinion advocates that ZIKV evolved into two distinct lineages, namely, African and Asian. Descendants of this latter lineage dispersed globally causing major epidemics. However, based on shared amino acid replacements and phylogenetic analyses, it was recently contentiously proposed that the Asian lineage was a direct descendant of the African lineage. To address this contentious issue, we reconstructed a phylogenetic tree of ZIKV using the method based on shared amino acid replacements and found that ZIKV evolved into two distinct lineages. This supports the conventional phylogenetic divergence pattern of ZIKV. Evidence of recombination and sequencing errors was identified among the large collection of ZIKV. As such problematic sequences could confound the phylogenetic analyses, they were removed. Bayesian phylogenetic analyses using the improved sequence data enabled estimates for the divergence time in the past of the African and Asian lineages of ∼180 years ago. Moreover, we found that the Asian lineage viruses did not evolve at an elevated rate. Our findings provide additional support for the conventional opinion that the Asian lineage of ZIKV diverged from the African lineage.
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