Trial reportJournal of applied oral science : revista FOB
Effectiveness of a new non-hydrogen peroxide bleaching agent after single use - a double-blind placebo-controlled short-term study.
Trial report in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Home-based chemically-induced whitening (bleaching) of teeth in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Comparative Evaluation of Different Teeth Whitening Agents on Extrinsic Stains: An In-Vitro Interventional Study.Journal of clinical and experimental dentistry · 2026Review
- Phthalimidoperoxycaproic Acid (PAP) Versus Peroxides and Impact on Dental Enamel After Whitening Treatment: An In Vitro Study.Journal of functional biomaterials · 2026Article
- Effectiveness of 10% Carbamide Peroxide in the Home Bleaching Technique on Vital Teeth: An Original Research.Journal of pharmacy & bioallied sciences · 2025Article
- Hydrogen Peroxide-Free Color Correctors for Tooth Whitening in Adolescents and Young Adults: A Systematic Review of In Vitro and Clinical Evidence.Dentistry journal · 2025Review
- Evaluation of Turkish Dentists' Approach to Over-the-Counter Whitening Agents: A Questionnaire-Based Study.Cureus · 2024Article
- Tooth-Whitening with a Novel Phthalimido Peroxy Caproic Acid: Short Communication.Clinical, cosmetic and investigational dentistry · 2024Article
- Effects of Time-Elapsed Bleaching on the Surface and Mechanical Properties of Dentin Substrate Using Hydrogen Peroxide-Free Nanohydroxyapatite Gel.International journal of nanomedicine · 2024Article
- Assessment of Color Change, Esthetic Perception, Treatment Satisfaction, and Side Effects Following the Use of Over-the-Counter Whitening Products.Acta stomatologica Croatica · 2023Article
- A Radical-Free Approach to Teeth Whitening.Dentistry journal · 2021Article
- Knowledge, Practices, and Perceptions about Tooth Whitening among Female Population in Saudi Arabia - A Cross-Sectional Study.Journal of pharmacy & bioallied sciences · 2021Article
- Nitrogen-Doped Titanium Dioxide Mixed with Calcium Peroxide and Methylcellulose for Dental Bleaching under Visible Light Activation.International journal of molecular sciences · 2021Article
- Evaluation of Three Different Bleaching Agents in Permanent and Primary Teeth: AnInternational journal of clinical pediatric dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTooth whitening represents perhaps the most common aesthetic procedure in dentistry worldwide. The efficacy of bleaching depends on three aspects: bleaching agent, bleaching method, and tooth color.
objectiveThis in vivo study aimed to examine whitening effects on frontal teeth of the upper and lower jaws using an over-the-counter (OTC) non-hydrogen peroxide bleaching agent in comparison to a placebo after one single use. MATERIAL AND
methodsForty subjects (25 female; 15 male) participated in this double-blind randomized placebo-controlled trial. The subjects were randomly allocated to two groups (n=20). The test group received the OTC product (iWhite Instant) and the placebo group received an identically composed product except for the active agents. Each subject was treated with a prefilled tray containing iWhite Instant or the placebo for 20 minutes. The tooth shade of the front teeth (upper and lower jaws) was assessed before (E_0), immediately after (E_1) and 24 h after treatment (E_2), using a shade guide (VITA classical). Statistical testing was accomplished using the Mann-Whitney U test (p<0.001). The dropout rate was 0%.
resultsThere were no significant differences at E_0 between placebo and test groups regarding the tooth color. Differences in tooth color changes immediately after (ΔE1_0) and 24 h after treatment (ΔE2_0) were calculated for both groups. The mean values (standard deviations) of tooth color changes for ΔE1_0 were 2.26 (0.92) in the test group and 0.01 (0.21) in the placebo group. The color changes for ΔE2_0 showed mean values of 2.15 (1.10) in the test group and 0.07 (0.35) in the placebo group. For ΔE1_0 and ΔE2_0 significant differences were found between the groups.
conclusionIn this short-term study, the results showed that a non-hydrogen peroxide bleaching agent has significant whitening effects immediately and 24 h after a single-use treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.