ArticleJournal of applied oral science : revista FOB
Agreement, correlation, and kinetics of the alveolar bone-loss measurement methodologies in a ligature-induced periodontitis animal model.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- N-acetylcysteine mitigates oxidative stress and reduces alveolar bone damage on experimental periodontitis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Advances in oral disease models: a mini-review of developments from 2015 to 2025.Frontiers in dental medicine · 2026Review
- Effect of resveratrol on the antioxidant enzyme pathway and alveolar bone loss in experimental periodontitis.Acta odontologica Scandinavica · 2025Article
- Omega-3 attenuates the severity of medication-related osteonecrosis of the jaws in rats treated with zoledronate.PloS one · 2025Article
- Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels.Biomedicines · 2024Article
- Minocycline reduces alveolar bone loss and bone damage in Wistar rats with experimental periodontitis.PloS one · 2024Article
- Physical training minimizes immunological dysfunction, oxidative stress and tissue destruction on experimental periodontitis in rats.PloS one · 2024Article
- Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats.Dentistry journal · 2023Article
- Evaluation of morphological, histological, and immune-related cellular changes in ligature-induced experimental periodontitis in mice.Journal of dental sciences · 2023Article
- Omega-3 Effects on Ligature-Induced Periodontitis in Rats with Fructose-Induced Metabolic Syndrome.Inflammation · 2023Article
- Article
- Açaí (Antioxidants (Basel, Switzerland) · 2022Article
- Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats.Molecules (Basel, Switzerland) · 2022Article
- Polymicrobial oral conventionalization model in mice.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.Environmental science and pollution research international · 2022Article
- Gan-Lu-Yin (Kanroin), Traditional Chinese Herbal Extracts, Reduces Osteoclast Differentiation In Vitro and Prevents Alveolar Bone Resorption in Rat Experimental PeriodontitisJournal of clinical medicine · 2021Article
- Ligature induced periodontitis causes atherosclerosis in rat descending aorta: an experimental study.Medicine and pharmacy reports · 2021Article
- Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease.International journal of experimental pathology · 2020Article
- Dynamic microstructural changes in alveolar bone in ligature-induced experimental periodontitis.Odontology · 2020Article
- Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal research involves the use of animal models to better understand the biological processes of periodontal diseases and the potential of new or existing therapies. Currently, ligature-induced periodontitis in rats is the main model used in periodontal research, in this model, alveolar bone loss (ABL) is the main parameter evaluated by radiographic, morphometric, and histological techniques. Interestingly, although these methodologies are widely used, it is not totally clarified neither the kinetics of ABL over the induction time nor the agreement degree (repeatability and reproducibility) of these techniques.
objectiveTo characterize ABL kinetics at 0, 3, 7, 15, 30, and 60 days after ABL induction by ligature and to evaluate the intra- (repeatability) and inter-examiner (reproducibility) agreement and the correlation among the radiographic, morphometric, and histological methodologies. MATERIAL AND
methods60 male Wistar rats with induced ABL were randomly divided into 6 experimental groups (n = 10 animals/group). After 0, 3, 7, 15, 30, and 60 days, the animals were euthanized and their hemimandibles were removed for ABL determination using radiographic, morphometric and histological techniques.
resultsRadiographic and morphometric/linear techniques allowed the detection of statistically significant ABL on the third day, while histological and morphometric/area techniques could only detect ABL after the seventh day (ANOVA/Tukey, p<0.05). After the fifteenth day, except for histological analysis, the ABL was stabilized. Concerning the agreement of the methodologies, Bland Altman's test (intra and inter-examiner evaluations) showed no difference among the measurements (p>0.05). In addition, high correlations (Pearson's test, r2>0.9, p<0.05) were observed.
conclusionThe results indicated that the minimum time for ABL induction could vary from 3 to 7 days, according to the chosen analysis methodology. Agreement and correlation data support the comparison of results between studies with same induction time.
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