ReviewJournal of applied oral science : revista FOB
Factors affecting the periapical healing process of endodontically treated teeth.
Review in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of QMix 2-in-1 as Final Irrigation Protocol on Periapical Healing After Single-visit Root Canal Treatment: a Randomized Controlled Trial
Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cements: An in Vivo Study With CBCT
Who cites it
83 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Analgesic Efficacy of Low-Level Laser Therapy for Postoperative Endodontic Pain: A Systematic Review and Meta-Analysis.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Pooled it
- Antimicrobial effectiveness of ultrasonic irrigation in root canal treatment: a systematic review of randomized clinical trials and meta-analysis.Clinical oral investigations · 2023Pooled it
- Do Calcium Chelators Play a Role in the Removal of Calcium Hydroxide From Root Canals? A Systematic Review of Laboratory Studies.European endodontic journal · 2022Pooled it
- Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review.BioMed research international · 2022Pooled it
- Healing Outcome of Different Aqueous-based Calcium Hydroxide Intracanal Medicament in Patients with Pulpal Necrosis and Symptomatic Apical Periodontitis: A Randomised Controlled Trial.European endodontic journal · 2025Trial
- Trial
- Regenerative Treatment of Mature Teeth with Pulp Necrosis and Apical Periodontitis Using Biodentine Compared with MTA: Randomized Controlled Clinical Trial.European endodontic journal · 2024Trial
- Impact XP-endo finisher on the 1-year follow-up success of posterior root canal treatments: a randomized clinical trial.Clinical oral investigations · 2023Trial
- Adjuvant therapy with a 980-nm diode laser in root canal retreatment: randomized clinical trial with 1-year follow-up.Lasers in medical science · 2023Trial
- Improbable healing in endodontics: a case series of favorable outcomes despite adverse prognostic conditions.BMC oral health · 2026Article
- Factors Influencing the Outcome of Iatrogenic Perforation Repair in Permanent Teeth-A Narrative Review.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Review
- Article
- Local Zoledronate Administration Modulates Periapical Lesion Development in Immunologically Distinct Rat Strains.Dentistry journal · 2026Article
- The Antimicrobial Efficacy of New Antibiotic Combinations against Bacteria Associated with Endo-perio Lesions in Deciduous Teeth: AnInternational journal of clinical pediatric dentistry · 2026Article
- Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss.International endodontic journal · 2026Article
- Bioactivity and dimensional stability of resin-, hybrid-, and silicate-based endodontic sealers: An in vitro comparative study.Journal of clinical and experimental dentistry · 2026Review
- Nutraceuticals for oral health: scientific rationale and clinical potential in endodontics.Acta odontologica Scandinavica · 2026Article
- Physicochemical and biological properties of three calcium silicate-based root canal sealers.PloS one · 2026Article
- Efficacy of Bioceramic Cements Versus Conventional Cements in the Prognosis of Endodontic Treatments in Patients with Apical Periodontitis: A Systematic Review with Meta-Analysis.Iranian endodontic journal · 2026Review
- A Modified Obturation Strategy Using the Piston Technique With a Calcium Silicate-Based Sealer in the Management of an Immature Necrotic Mandibular Second Molar: A Case Report.Case reports in dentistry · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing. This review aims to discuss the important therapeutic factors associated with the clinical protocol used during root canal treatment and to highlight the systemic conditions associated with the periapical healing process of endodontically treated teeth. The antibacterial strategies indicated in the conventional treatment of an inflamed and infected pulp and the modulation of the host's immune response may assist in tissue repair, if wound healing has been hindered by infection. Systemic conditions, such as diabetes mellitus and hypertension, can also inhibit wound healing. The success of root canal treatment is affected by the correct choice of clinical protocol. These factors are dependent on the sanitization process (instrumentation, irrigant solution, irrigating strategies, and intracanal dressing), the apical limit of the root canal preparation and obturation, and the quality of the sealer. The challenges affecting the healing process of endodontically treated teeth include control of the inflammation of pulp or infectious processes and simultaneous neutralization of unpredictable provocations to the periapical tissue. Along with these factors, one must understand the local and general clinical conditions (systemic health of the patient) that affect the outcome of root canal treatment prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.