Evidence map›Paper›PMID 29069088›Full record

ArticlePloS one2017

Donation of peripheral blood stem cells to unrelated strangers: A thematic analysis.

Annelies Billen, J Alejandro Madrigal, Katrina Scior, Bronwen E Shaw, Andre Strydom

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05595382 (Motivations for Stem Cell Transplant Registry Participation), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05595382 nacompletednot on this mapstarted 2022, after this paper: background citation

Motivations for Stem Cell Transplant Registry Participation

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2022 to 2023Enrolled397ConditionsHealthyArmsEmotional Appeal, Rational Appeal
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Supportive Care of Hematopoietic Stem Cell Donors.Clinical hematology international · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Annelies BillenAnthony Nolan, London, United Kingdom.
J Alejandro MadrigalAnthony Nolan, London, United Kingdom.
Katrina SciorUCL Research Department of Clinical, Educational and Health Psychology, London, United Kingdom.
Bronwen E ShawAnthony Nolan, London, United Kingdom.
Andre StrydomUCL Mental Health Sciences Unit, London, United Kingdom.
University College London · GBCRUK Lung Cancer Centre of Excellence · GBMedical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDonation of haematopoietic stem cells, either through bone marrow (BM) or peripheral blood stem cell (PBSC) collection, is a generally safe procedure for healthy donors, although side effects are a known risk. Previous research, including our recent quantitative study, has shown that the psychosocial response to donating is usually a positive one and most donors would be willing to donate again in the future. This is often despite experiencing significant side effects during the donation process. Due to the relative recent introduction of PBSC, a comprehensive understanding of the range of physical and emotional issues donors may experience is lacking, as well as an understanding of specific donor characteristics Qualitative research can provide rich narrative data into these areas. This study was set up in order to identify specific donor characteristics and to further explore the relationship between pre-donation physical health and the donation experience, as previously identified in our quantitative study.

methodsIt involved in-depth telephone interviews with 14 PBSC donors who participated in our original quantitative study. Thematic analysis was used to analyse the findings and the results provide a summary of participants' characteristics using themes and constituent codes.

resultsWe identified several donor characteristics, including strong intrinsic motivation, altruism, sense of duty, determination, low levels of ambivalence and the ability to develop a strong emotional relationship with an (unknown/anonymous) recipient whilst being able to manage strong feelings and emotions.

conclusionsThese personality traits may explain the resilience that has been observed previously in haematopoietic stem cells donors. Significant feelings of grief were reported after a recipient's death. Possibilities to alleviate these symptoms may include raising awareness of potential poor outcomes in the recipient and offering improved counselling services if the recipient dies. We acknowledge several limitations including the sampling frame.

Indexed as

Blood DonorsPeripheral Blood Stem CellsAdultFemaleHumansMaleMiddle AgedPeripheral Blood Stem Cell TransplantationYoung Adult

Identifiers

PMID29069088
PMCPMC5656410
OpenAlexW2765269043

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.