ArticleMedicine2017
Predictive factors associated with neck pain in patients with cervical disc degeneration: A cross-sectional study focusing on Modic changes.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Effectiveness of percutaneous neuromuscular electrical stimulation for neck pain relief in patients with cervical spondylosis.Medicine · 2018Trial
- Associated Factors with Neck Pain among Productive Adult Motorcyclists in Metropolitan University Settings : A Cross-Sectional Study.Journal of Korean Neurosurgical Society · 2025Article
- Increased cervical disc degeneration in ischemic stroke: a 10-year retrospective data review.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Prevalence and Risk Factors for Modic Changes in Symptomatic Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Study of 203 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Longitudinal assessment of annular fissures of the cervical spine: overlooked and static.North American Spine Society journal · 2023Article
- Modic Changes of the Cervical and Lumbar Spine and Their Effect on Neck and Back Pain: A Systematic Review and Meta-Analysis.Global spine journal · 2023Review
- Temporomandibular Joint Disk Displacements in Class II Malocclusion and Cervical Spine Alterations: Systematic Review and Report of a Hypodivergent Case with MRI Bone and Soft Tissue Changes.Life (Basel, Switzerland) · 2022Review
- Cervical disc degeneration: important considerations for the manual therapist.The Journal of manual & manipulative therapy · 2022Review
- Sensitivity of the Cervical Disc Loads, Translations, Intradiscal Pressure, and Muscle Activity Due to Segmental Mass, Disc Stiffness, and Muscle Strength in an Upright Neutral Posture.Frontiers in bioengineering and biotechnology · 2022Article
- Analysis of the clinical and radiological outcomes of percutaneous cervical nucleoplasty: A case-control study.PloS one · 2022Article
- Associations between clinical neck symptoms and various evaluations ofcervical intervertebral disc degeneration by magnetic resonance imaging.Fukushima journal of medical science · 2021Article
- 2021 Position Statement From the International Society for the Advancement of Spine Surgery on Cervical and Lumbar Disc Replacement.International journal of spine surgery · 2021Article
- Relation Between Neck Pain and Modic Changes in Cervical Spondylotic Myelopathy.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Cervical sagittal alignment in adolescent high dysplastic developmental spondylolisthesis: how does the cervical spine respond to the reduction of spondylolisthesis?Journal of orthopaedic surgery and research · 2020Article
- The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients.Neurospine · 2020Article
- Prevalence of cervical spine degenerative changes in elderly population and its weak association with aging, neck pain, and osteoporosis.Annals of translational medicine · 2019Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predictive factors associated with neck pain remain unclear. We conducted a cross-sectional study to assess predictive factors, especially Modic changes (MCs), associated with the intensity and duration of neck pain in patients with cervical disc degenerative disease.We retrospectively reviewed patients in our hospital from January 2013 to December 2016. Severe neck pain (SNP) and persistent neck pain (PNP) were the 2 main outcomes, and were assessed based on the numerical rating scale (NRS). Basic data, and also imaging data, were collected and analyzed as potential predictive factors. Univariate analysis and multiple logistic regression analysis were performed to assess the predictive factors for neck pain.In all, 381 patients (193 males and 188 females) with cervical degenerative disease were included in our study. The number of patients with SNP and PNP were 94 (24.67%) and 109 (28.61%), respectively. The NRS of neck pain in patients with type 1 MCs was significantly higher than type 2 MCs (4.8 ± 0.9 vs 3.9 ± 1.1; P = .004). The multivariate logistic analysis showed that kyphosis curvature (odds ratio [OR] 1.082, 95% confidence interval [CI] 1.044-1.112), spondylolisthesis (OR 1.339, 95% CI 1.226-1.462), and annular tear (OR 1.188, 95% CI 1.021-1.382) were factors associated with SNP, whereas kyphosis curvature (OR 1.568, 95% CI 1.022-2.394), spondylolisthesis (OR 1.486, 95% CI 1.082-2.041), and MCs (OR 1.152, 95% CI 1.074-1.234) were associated with PNP.We concluded that kyphosis curvature, spondylolisthesis, and annular tear are associated with SNP, whereas kyphosis curvature, spondylolisthesis, and MCs are associated with PNP. This study supports the view that MCs can lead to a long duration of neck pain.
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