Observational studyMedicine2017
Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP): An observational cohort study.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Prevalence and impact of thyroid dysfunction in patients with rheumatoid arthritis.Scientific reports · 2025Article
- Thyroid Status in Rheumatoid Arthritis.Cureus · 2025Article
- CORRELATION OF TPO ANTIBODY CONCENTRATION WITH THYROID HORMONES AS A PREDICTOR OF CLINICAL HYPOTHYROIDISM.Acta clinica Croatica · 2024Article
- Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet.Clinical rheumatology · 2024Review
- The association between thyroid dysfunction, autoimmune thyroid disease, and rheumatoid arthritis disease severity.BMC endocrine disorders · 2023Article
- Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry.Pediatric rheumatology online journal · 2023Article
- Article
- The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis.BMC rheumatology · 2022Article
- Correlation of Hypothyroidism With Disease Activity Score-28 in Patients of Rheumatoid Arthritis.Cureus · 2022Article
- Changes in Thyroid Hormone Signaling Mediate Cardiac Dysfunction in the Tg197 Mouse Model of Arthritis: Potential Therapeutic Implications.Journal of clinical medicine · 2021Article
- Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.PloS one · 2021Article
- Fetuin-A and thyroxin binding globulin predict rituximab response in rheumatoid arthritis patients with insufficient response to anti-TNFα.Clinical rheumatology · 2020Article
- Does autoimmune thyroid disease affect rheumatoid arthritis disease activity or response to methotrexate?RMD open · 2020Article
- Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction.The Journal of international medical research · 2020Article
- Prevalence of Undiagnosed Hypothyroidism in Europe: A Systematic Review and Meta-Analysis.European thyroid journal · 2019Review
- Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis.Mediators of inflammation · 2019Review
- Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry. Patients' electronic hospital records for the past 10 years were reviewed to reveal if they had been diagnosed with thyroid disorders or they had abnormal thyroid test.In all, 439 patients were included, female 60.1%, mean age 64.6 ± 15.0 years and disease duration 2.6 ± 1.7 years. Prevalence of thyroid disorders was 69/439 (15.7%) and hypothyroidism was the most frequent disorder (30.4%). The presence of thyroid disorders among RA patients was significantly associated with female sex (P < .001), ANA positivity (P = .04), and anti-CCP ≥100 EU/mL (P = .05). Furthermore, RA patients with thyroid disorders had significantly poorer initial response to RA treatment compared with patients with isolated RA after 4 months of treatment (P = .02). There were no associations between thyroid disorders and age, disease duration, and also IgM RF positivity.Presence of thyroid disorders in RA patients is suggestive of a more aggressive disease and poor outcome, with direct effect on initial treatment response. To diagnose concurrent thyroid disorders at an earlier stage, routine measurement of serum thyroid-stimulating hormone is recommended in all RA patients at the time of diagnosis and with yearly interval thereafter.
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