Evidence map›Paper›PMID 29068906›Full record

ArticleMedical care2017

Regional Medicare Expenditures and Survival Among Older Women With Localized Breast Cancer.

Sara Tannenbaum, Pamela R Soulos, Jeph Herrin, Sarah Mougalian, Jessica B Long, Rong Wang, Xiaomei Ma, Cary P Gross, Xiao Xu

Open access · greenAbstract read
In one paragraph

Article in Medical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Association Between Spending and Outcomes for Patients With Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sara Tannenbaum*Yale School of Medicine†Section of General Internal Medicine, Department of Internal Medicine, Yale School of Medicine‡Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center, Yale University§Division of Cardiology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT∥Health Research and Educational Trust, Chicago, IL¶Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine#Department of Chronic Disease Epidemiology, Yale School of Public Health**Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT.
Pamela R Soulos
Jeph Herrin
Sarah Mougalian
Jessica B Long
Rong Wang
Xiaomei Ma
Cary P Gross
Xiao Xu
Yale Cancer Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Use and Outcomes of Radiation Therapy for Medicare Patients with Common CancersR01CA149045 · NCI · YALE UNIVERSITY · PI GROSS, CARY P. · 2010 to 2012
$1.5M
NCATS NIH HHS UL1 TR001863NCI NIH HHS N01 PC035136NCI NIH HHS N01 PC035139NCI NIH HHS N02 PC015105NCI NIH HHS R01 CA149045
6 · The paper itself

Abstract

backgroundDespite evidence on large variation in breast cancer expenditures across geographic regions, there is little understanding about the association between expenditures and patient outcomes.

objectivesTo examine whether Medicare beneficiaries with nonmetastatic breast cancer living in regions with higher cancer-related expenditures had better survival. RESEARCH

designA retrospective cohort study of women with localized breast cancer from the Surveillance, Epidemiology, and End Results-Medicare linked database. Hospital referral regions (HRR) were categorized into quintiles based on risk-standardized per patient Medicare expenditures on initial phase of breast cancer care. Hierarchical generalized linear models were estimated to examine the association between patients' HRR quintile and survival. SUBJECTS: In total, 12,610 Medicare beneficiaries diagnosed with stage II-III breast cancer during 2005-2008 who underwent surgery. MEASURES: Outcome measures for our analysis were 3- and 5-year overall survival.

resultsRisk-standardized per patient Medicare expenditures on initial phase of breast cancer care ranged from $13,338 to $26,831 across the HRRs. Unadjusted 3- and 5-year survival varied from 66.7% to 92.2% and 50.0% to 84.0%, respectively, across the HRRs, but there was no significant association between HRR quintile and survival in bivariate analysis (P=0.08 and 0.28, respectively). After adjustment for sociodemographic and clinical characteristics, quintiles of regional cancer expenditures remained unassociated with patients' 3-year (P=0.35) and 5-year survival (P=0.20). Further analysis adjusting for treatment factors (surgery type and receipt of radiation and systemic therapy) and stratifying by cancer stage showed similar results.

conclusionsFor Medicare beneficiaries with nonmetastatic breast cancer, residence in regions with higher breast cancer-related expenditures was not associated with better survival. More attention to value in breast cancer care is warranted.

Indexed as

AgedAged, 80 and overBreast NeoplasmsCohort StudiesFemaleHealth ExpendituresHospital PlanningHumansMedicareNeoplasm StagingReferral and ConsultationResidence CharacteristicsRetrospective StudiesSocioeconomic FactorsUnited States

Identifiers

PMID29068906
PMCPMC5863278
OpenAlexW2766039195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.