ArticleInternational journal of molecular sciences2017
Association of Smoking with Metabolic Volatile Organic Compounds in Exhaled Breath.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Respirator-integrated continuous gas sampling for broadband optical spectroscopy.Scientific reports · 2026Article
- Electronic nose technology in bronchial asthma diagnosis and management.Multidisciplinary respiratory medicine · 2026Article
- Determination of lung cancer exhaled breath biomarkers using machine learning-a new analysis framework.Scientific reports · 2025Article
- Integrated exposomic analysis of lipid phenotypes: Leveraging GE.db in environment by environment interaction studies.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Exhaled volatile organic compounds associated with risk factors for obstructive pulmonary diseases: a systematic review.ERJ open research · 2023Review
- Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation.Frontiers in bioengineering and biotechnology · 2022Article
- The influence of terpenes on the release of volatile organic compounds and active ingredients to cannabis vaping aerosols.RSC advances · 2021Article
- Data preprocessing workflow for exhaled breath analysis by GC/MS using open sources.Scientific reports · 2020Article
- The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease.Biosensors · 2020Review
- Breath analysis as a diagnostic and screening tool for malignant pleural mesothelioma: a systematic review.Translational lung cancer research · 2018Review
- Blood based biomarkers beyond genomics for lung cancer screening.Translational lung cancer research · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer (LC) screening will be more efficient if it is applied to a well-defined high-risk population. Characteristics including metabolic byproducts may be taken into account to access LC risk more precisely. Breath examination provides a non-invasive method to monitor metabolic byproducts. However, the association between volatile organic compounds (VOCs) in exhaled breath and LC risk or LC risk factors is not studied. Exhaled breath samples from 122 healthy persons, who were given routine annual exam from December 2015 to December 2016, were analyzed using thermal desorption coupled with gas chromatography mass spectrometry (TD-GC-MS). Smoking characteristics, air quality, and other risk factors for lung cancer were collected. Univariate and multivariate analyses were used to evaluate the relationship between VOCs and LC risk factors. 7, 7, 11, and 27 VOCs were correlated with smoking status, smoking intensity, years of smoking, and depth of inhalation, respectively. Exhaled VOCs are related to smoking and might have a potential to evaluate LC risk more precisely. Both an assessment of temporal stability and testing in a prospective study are needed to establish the performance of VOCs such as 2,5-dimethylfuranm and 4-methyloctane as lung cancer risk biomarkers.
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Registered trials
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