ArticleeLife2017
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.
Abstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells.Chembiochem : a European journal of chemical biology · 2026Review
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2025Review
- RIM and MUNC13 membrane-binding domains are essential for neuropeptide secretion.The Journal of cell biology · 2025Article
- TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion.Diabetologia · 2025Article
- Single-Vesicle Microelectroanalysis Reveals the Role of PIP2 Phospholipid in Vesicle Opening Dynamics and Its Potential Role in Exocytosis.ACS omega · 2025Article
- Lipid probes to study ion channels.Current opinion in chemical biology · 2025Review
- Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025Review
- TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion.bioRxiv : the preprint server for biology · 2024Article
- Phosphoinositide switches in cell physiology - From molecular mechanisms to disease.The Journal of biological chemistry · 2024Review
- Quantifying single-cell diacylglycerol signaling kinetics after uncaging.Biophysical journal · 2023Article
- Chemical Approaches for Measuring and Manipulating Lipids at the Organelle Level.Cold Spring Harbor perspectives in biology · 2023Review
- Chemical Tools for Lipid Cell Biology.Accounts of chemical research · 2023Article
- An approach for quantitative mapping of synaptic periactive zone architecture and organization.Molecular biology of the cell · 2023Article
- PLC regulates spontaneous glutamate release triggered by extracellular calcium and readily releasable pool size in neocortical neurons.Frontiers in cellular neuroscience · 2023Article
- Role of Lysosomal Cholesterol in Regulating PI(4,5)PAdvances in experimental medicine and biology · 2023Article
- Phosphoinositides as membrane organizers.Nature reviews. Molecular cell biology · 2022Review
- Article
- Sequential compound fusion and kiss-and-run mediate exo- and endocytosis in excitable cells.Science advances · 2022Article
- Molecular mechanisms for ABCA1-mediated cholesterol efflux.Cell cycle (Georgetown, Tex.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Alexander M Walter *Neurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5646-4750
Rainer Müller *Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3464-494X
Bassam Tawfik *Neurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1193-8494
Keimpe Db WierdaNeurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-8784-9490
Paulo S PinheiroNeurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
André NadlerCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Anthony W McCarthyLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.ORCID http://orcid.org/0000-0002-3771-351X
Iwona ZiomkiewiczNeurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Martin KruseDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, United States.
Gregor ReitherCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Jens RettigCellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
Martin LehmannLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Volker HauckeLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Bertil HilleDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, United States.
Carsten SchultzCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Jakob Balslev SørensenNeurosecretion group, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5465-3769
Funding
Molecular Properties of Ionic Permeability in NerveR37NS008174 · NINDS · UNIVERSITY OF WASHINGTON · PI HILLE, BERTIL · 2013 to 2019
$3.8MNINDS NIH HHS R37 NS008174
Abstract
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P
Indexed as
ExocytosisAnimalsCarrier ProteinsCell LineChromaffin CellsCytological TechniquesIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateSynaptotagmin ICarrier ProteinsCybr protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateSynaptotagmin ISyt1 protein, mouseUnc13b protein, mouseadrenal chromaffin cellcell biologyexocytosismouseMunc13neuroscienceoptical uncagingphosphatidylinositolssynaptotagmin
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.