ArticleLangmuir : the ACS journal of surfaces and colloids2017
Quantifying Binding of Ethylene Oxide-Propylene Oxide Block Copolymers with Lipid Bilayers.
Article in Langmuir : the ACS journal of surfaces and colloids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Exploring the Limits of Passive Macromolecular Translocation through Phospholipid Membranes.Biomacromolecules · 2025Article
- Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Concentration Threshold for Membrane Protection by PEO-PPO Block Copolymers with Variable Molecular Architectures.ACS applied polymer materials · 2022Article
- Synthesis and Micellization of Bottlebrush Poloxamers.ACS macro letters · 2022Article
- Lipid Membrane Binding and Cell Protection Efficacy of Poly(1,2-butylene oxide)-Biomacromolecules · 2022Article
- Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells but Does Not Select for Them Relative to Unjoined Amino Acids.The journal of physical chemistry. B · 2021Article
- Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics.Communications chemistry · 2021Article
- Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers.The journal of physical chemistry. B · 2020Article
- Rational design of block copolymer self-assemblies in photodynamic therapy.Beilstein journal of nanotechnology · 2020Review
- Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Influence of Cholesterol and Bilayer Curvature on the Interaction of PPO-PEO Block Copolymers with Liposomes.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.JACC. Basic to translational science · 2019Review
- PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes.PloS one · 2019Article
- Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers.Skeletal muscle · 2018Review
- Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications.Acta pharmaceutica Sinica. B · 2018Review
- Surface Plasmon Resonance Study of the Binding of PEO-PPO-PEO Triblock Copolymer and PEO Homopolymer to Supported Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Block copolymers composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) have been widely used in cell membrane stabilization and permeabilization. To explore the mechanism of interaction between PPO-PEO block copolymers and lipid membranes, we have investigated how polymer structure influences the polymer-lipid bilayer association by varying the overall molecular weight, the hydrophobic and hydrophilic block lengths, and the end-group structure systematically, using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) unilamellar liposomes as model membranes. Pulsed-field-gradient NMR (PFG-NMR) was employed to probe polymer diffusion in the absence and presence of liposomes. The echo decay curves of free polymers in the absence of liposomes are single exponentials, indicative of simple translational diffusion, while in the presence of liposomes, the decays are biexponential, with the slower decay corresponding to polymers bound to liposomes. The binding percentage of polymer to the liposome was quantified by fitting the echo decay curves to a biexponential model. The NMR experiments show that increasing the total molecular weight and hydrophobicity of the polymer can significantly enhance the polymer-lipid bilayer association, as the binding percentage and liposome surface coverage both increase. We hypothesize that the hydrophobic PPO block inserts into the lipid bilayer due to the fact that little molecular exchange between bound and free polymers occurs on the time scale of the diffusion experiments. Additionally, as polymer concentration increases, the liposome surface coverage increases and approaches a limit. These results demonstrate that PFG-NMR is a simple yet powerful method to quantify interactions between polymers and lipid bilayers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.