ArticleJBRA assisted reproduction2017
Semen parameters in men with varicocele: DNA fragmentation, chromatin packaging, mitochondrial membrane potential, and apoptosis.
Article in JBRA assisted reproduction, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- The role of the mitochondrial injury-mediated oxidative stress-sterile inflammation axis in varicocele-induced infertility: a narrative review.Basic and clinical andrology · 2026Review
- Small RNA profile alterations as a potential mechanism for sperm quality improvement following varicocelectomy.Asian journal of andrology · 2026Article
- Electroacupuncture for sperm improvement in varicocele: a case report.The Canadian journal of urology · 2026Article
- Sperm DNA Fragmentation in Men with Varicocele: A Systematic Review and Meta-Analysis.The world journal of men's health · 2026Article
- Density gradient centrifugation versus swim-up for selecting spermatozoa with improved redox activity, calcium status, and DNA integrity in an established rat model of varicocele-induced infertility.Frontiers in cell and developmental biology · 2026Article
- The role of sperm DNA fragmentation in reproduction: a SWOT analysis.Journal of assisted reproduction and genetics · 2025Review
- The role of the intrinsic pathway of apoptosis in human ejaculated sperm damage under a state of scrotal heat stress.Journal of assisted reproduction and genetics · 2024Article
- Varicocele: To Treat or Not to Treat?Journal of clinical medicine · 2023Review
- Negative effect of varicocele on sperm mitochondrial dysfunction: A cross-sectional study.International journal of reproductive biomedicine · 2023Article
- Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.Communications biology · 2021Review
- Is ferroptosis involved in ROS-induced testicular lesions in a varicocele rat model?Basic and clinical andrology · 2021Article
- Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020Review
- Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility.The world journal of men's health · 2020Review
- Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis.Reproductive biology and endocrinology : RB&E · 2019Review
- Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele.The world journal of men's health · 2018Article
- Sperm DNA fragmentation.Translational andrology and urology · 2017Article
- From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected subfertile men.International braz j urol : official journal of the Brazilian Society of UrologyReview
- Moment of induction and duration of experimental varicocele in rats: effects on semen quality.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Oxidative origin of sperm DNA fragmentation in the adult varicocele.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate varicocele effects on conventional semen parameters: sperm DNA fragmentation, chromatin packaging, mitochondrial membrane potential (MMP) and sperm apoptosis.
methodsA cross-sectional study was carried out with semen samples from 2,399 men of couples who attended an infertility clinic. A total of 16.3% (391/2399) of the men were diagnosed with varicocele by a urologist.
resultsA regression analysis revealed that the percentages of sperm with DNA fragmentation, abnormal chromatin packaging, and abnormal MMP were significantly increased in individuals with varicocele, when compared to men without varicocele. Apoptosis was not influenced by varicocele. Conventional semen parameters were significantly worse in individuals with the disease. On the other hand, in men with varicocele, Spearman's correlation demonstrated that early apoptosis and abnormal MMP showed a positive and significant correlation with sperm DNA fragmentation.
conclusionMen with varicocele had worse semen parameters, including increased levels of sperm DNA fragmentation, inactive mitochondria, and abnormal chromatin packaging. These changes are possible causes of infertility in individuals with varicocele.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.