Evidence map›Paper›PMID 29067994›Full record

ArticleMucosal immunology2018

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.

A Cait, M R Hughes, F Antignano, J Cait, P A Dimitriu, K R Maas, L A Reynolds, L Hacker, J Mohr, B B Finlay and 3 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed, 6 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

257 citing papers in PubMed, 6 syntheses or guidelines pooled it, 375 citations in OpenAlex.

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  13. Journal of pharmaceutical analysis · 2026
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197 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

A CaitDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
M R HughesThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
F AntignanoThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
J CaitThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
P A DimitriuDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
K R MaasDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
L A ReynoldsMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
L HackerThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
J MohrThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
B B FinlayDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
C ZaphDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
K M McNagnyThe Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
W W MohnDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mammalian gastrointestinal tract harbors a microbial community with metabolic activity critical for host health, including metabolites that can modulate effector functions of immune cells. Mice treated with vancomycin have an altered microbiome and metabolite profile, exhibit exacerbated T helper type 2 cell (Th2) responses, and are more susceptible to allergic lung inflammation. Here we show that dietary supplementation with short-chain fatty acids (SCFAs) ameliorates this enhanced asthma susceptibility by modulating the activity of T cells and dendritic cells (DCs). Dysbiotic mice treated with SCFAs have fewer interleukin-4 (IL4)-producing CD4

Indexed as

AllergensAnimalsAntigen PresentationAsthmaChemokine CCL19Dendritic CellsDietary SupplementsDysbiosisFatty Acids, VolatileGastrointestinal MicrobiomeHypersensitivityInterleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutAllergensCcl19 protein, mouseChemokine CCL19Fatty Acids, VolatileInterleukin-4Vancomycin

Identifiers

PMID29067994
OpenAlexW2765759949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.