Evidence map›Paper›PMID 29067979›Full record

ArticleThe Indian journal of medical research2017

Peripheral blood mononuclear cells of patients with latent autoimmune diabetes secrete higher levels of pro- & anti-inflammatory cytokines compared to those with type-1 diabetes mellitus following

Darshan Badal, Rajendra Kumar, Mahinder Paul, Devi Dayal, Anil Bhansali, Sanjay Kumar Bhadada, Rajesh Kumar, Naresh Sachdeva

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Indian journal of medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Darshan BadalDepartment of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Rajendra KumarUniversity Institute of Pharmaceutical Sciences (UIPS), Chandigarh, India.
Mahinder PaulDepartment of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Devi DayalDepartment of Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Anil BhansaliDepartment of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Sanjay Kumar BhadadaDepartment of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Rajesh KumarDepartment of Statistics, Panjab University, Chandigarh, India.
Naresh SachdevaDepartment of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Post Graduate Institute of Medical Education and Research · INPanjab University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesType-1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA) share similar pathological features but differ in age of onset and progression. There is a scarcity of information on differences in CD4+ T-cell responses, particularly, cytokine secretion, between the two forms of autoimmune diabetes. Here proliferative potential and concentration of pro- and anti-inflammatory cytokines secreted by peripheral blood mononuclear cells (PBMCs) of T1DM and LADA patients were compared, after in vitro stimulation with β-cell autoantigens.

methodsA total of 19 patients with LADA, 37 with T1DM and 20 healthy controls were compared on the basis of lymphocyte proliferation and secretion of pro- and anti-inflammatory cytokines belonging to different T-helper types after in vitro stimulation of PBMCs with insulin and glutamic acid decarboxylase 65 (GAD65).

resultsFollowing insulin stimulation, LADA group secreted higher concentration of interleukin-17 (IL-17) (P=0.02) and had higher proportion of interferon gamma (IFN-γ) secretors (P<0.001) than T1DM group. Post-GAD65 stimulation, higher proportion of LADA patients secreted IL-23 than T1DM group (P=0.02). Proportion of responders , as well as levels of secreted IL-10, were significantly higher in LADA than T1DM group, following stimulation with both insulin (P=0.01) and GAD65 (P=0.03). A significant positive correlation was observed between body mass index and IL-17 levels (r=0.41, P=0.04) and fasting plasma C-peptide with IL-10 levels (r=0.37, P=0.04). INTERPRETATION &

conclusionsThere are differences in the portfolio of cytokine secretion in diabetic subjects with varying rates of β-cell destruction as LADA subjects secrete higher levels of both pro- and anti-inflammatory cytokines on exposure to β-cell autoantigens, thus highlighting another distinguishing feature in the pathophysiology of the two forms of autoimmune diabetes.

Indexed as

Diagnosis, DifferentialAdolescentAdultAutoantibodiesAutoantigensCD4-Positive T-LymphocytesChildCytokinesDiabetes Mellitus, Type 1FemaleGlutamate DecarboxylaseHumansInsulinInsulin-Secreting CellsInterferon-gammaInterleukin-10AutoantibodiesAutoantigensCytokinesGlutamate Decarboxylaseglutamate decarboxylase 2IL10 protein, humanInsulinInterferon-gammaInterleukin-10Interleukin-17Interleukin-23

Identifiers

PMID29067979
PMCPMC5674547
OpenAlexW2770504624

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.