Evidence map›Paper›PMID 29067749›Full record

Trial reportNeuromodulation : journal of the International Neuromodulation Society2018

Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.

Isabella S Menezes, Leonardo G Cohen, Eduardo A Mello, André G Machado, Paul Hunter Peckham, Sarah M Anjos, Inara L Siqueira, Juliana Conti, Ela B Plow, Adriana B Conforto

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  17. Searching for the optimal tDCS target for motor rehabilitation.Journal of neuroengineering and rehabilitation · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Isabella S MenezesHospital das Clinicas/São Paulo University, São Paulo, Brazil.
Leonardo G CohenHuman Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Eduardo A MelloHospital das Clinicas/São Paulo University, São Paulo, Brazil.
André G MachadoDepartament of Neurosciences, Lerner Reasearch Institute, Cleveland Clinic, Cleveland, OH, USA.
Paul Hunter PeckhamCase Western Reserve University, Cleveland, OH, USA.
Sarah M AnjosHospital das Clinicas/São Paulo University, São Paulo, Brazil.
Inara L SiqueiraHospital das Clinicas/São Paulo University, São Paulo, Brazil.
Juliana ContiHospital das Clinicas/São Paulo University, São Paulo, Brazil.
Ela B PlowDepartament of Neurosciences, Lerner Reasearch Institute, Cleveland Clinic, Cleveland, OH, USA.
Adriana B ConfortoHospital das Clinicas/São Paulo University, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRCase Western Reserve University · USCleveland Clinic Lerner College of Medicine · USNational Institute of Neurological Disorders and Stroke · US

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Brain Stimulation- aided Stroke Rehabilitation: Neural Mechanisms of RecoveryK01HD069504 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, ELA B · 2011 to 2015
$531k
Combined brain and peripheral nerve stimulation to enhance beneficial effects ofR01NS076348 · NINDS · FUNDACAO FACULDADE DE MEDICINA · PI CONFORTO, ADRIANA B · 2012 to 2015
$441k
Novel strategies for stroke rehabilitation (planning grant)D71TW009132 · FIC · FUNDACAO FACULDADE DE MEDICINA · PI CONFORTO, ADRIANA B · 2011 to 2012
$58k
FIC NIH HHS D71 TW009132NICHD NIH HHS K01 HD069504NINDS NIH HHS R01 NS076348
6 · The paper itself

Abstract

objectivesTo evaluate effects of somatosensory stimulation in the form of repetitive peripheral nerve sensory stimulation (RPSS) in combination with transcranial direct current stimulation (tDCS), tDCS alone, RPSS alone, or sham RPSS + tDCS as add-on interventions to training of wrist extension with functional electrical stimulation (FES), in chronic stroke patients with moderate to severe upper limb impairments in a crossover design. We hypothesized that the combination of RPSS and tDCS would enhance the effects of FES on active range of movement (ROM) of the paretic wrist to a greater extent than RPSS alone, tDCS alone or sham RPSS + tDCS. MATERIALS AND

methodsThe primary outcome was the active ROM of extension of the paretic wrist. Secondary outcomes were ROM of wrist flexion, grasp, and pinch strength of the paretic and nonparetic upper limbs, and ROM of wrist extension of the nonparetic wrist. Outcomes were blindly evaluated before and after each intervention. Analysis of variance with repeated measures with factors "session" and "time" was performed.

resultsAfter screening 2499 subjects, 22 were included. Data from 20 subjects were analyzed. There were significant effects of "time" for grasp force of the paretic limb and for ROM of wrist extension of the nonparetic limb, but no effects of "session" or interaction "session x time." There were no significant effects of "session," "time," or interaction "session x time" regarding other outcomes.

conclusionsSingle sessions of PSS + tDCS, tDCS alone, or RPSS alone did not improve training effects in chronic stroke patients with moderate to severe impairment.

Indexed as

Transcranial Direct Current StimulationTranscutaneous Electric Nerve StimulationAdultAgedBrainChronic DiseaseCombined Modality TherapyDouble-Blind MethodFemaleHumansMaleMedian NerveMiddle AgedMovement DisordersOutcome Assessment, Health CarePeripheral Nervous SystemElectric stimulation therapymotor skillssensory functionstroke rehabilitationtranscranial direct current stimulationtranscutaneous electric nerve stimulation

Identifiers

PMID29067749
PMCPMC5801160
OpenAlexW2766265094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.