ArticleTransfusion2017
Demographic and epidemiologic characterization of transfusion recipients from four US regions: evidence from the REDS-III recipient database.
Article in Transfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 97 citations in OpenAlex.
- Trial
- Equivalent inpatient mortality among direct-acting oral anticoagulant and warfarin users presenting with major hemorrhage.Thrombosis research · 2020Trial
- Red Cell Transfusion in General Medicine Patients at Teaching and Non-teaching Hospitals: A Retrospective Cohort Analysis.Journal of general internal medicine · 2026Article
- Integrated analysis of blood donor metabolic phenotypes and genetic traits on red blood cell transfusion effectiveness.Blood red cells & iron · 2025Article
- Electronic health records reveal variations in the use of blood units by hour and medical specialty.Vox sanguinis · 2025Article
- An agnostic study of donor and component factors associated with transfusion-related changes in laboratory markers.Transfusion · 2025Article
- Developing A Model to Predict Major Bleeding Among Hospitalized Patients Undergoing Therapeutic Plasma Exchange.Journal of clinical apheresis · 2025Article
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- Article
- Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.Cell metabolism · 2024Article
- Article
- Clinical outcomes in hospitalized plasma and platelet transfusion recipients prior to and following widespread blood donor SARS-CoV-2 infection and vaccination.Transfusion · 2024Article
- In hospitalized patients undergoing therapeutic plasma exchange, major bleeding prevalence depends on the bleeding definition: An analysis of The Recipient Epidemiology and Donor Evaluation Study-III.Journal of clinical apheresis · 2023Article
- Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.Frontiers in immunology · 2023Article
- Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors.Critical care (London, England) · 2022Article
- Adverse events of red blood cell transfusions in patients with sickle cell disease.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Review
- Analyzing real world data of blood transfusion adverse events: Opportunities and challenges.Transfusion · 2022Article
- Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness.JCI insight · 2022Article
- How do the threshold values used in the decision on red blood cell and platelet transfusions comply with the guidelines?Northern clinics of Istanbul · 2022Article
- Profiles of Whole Blood Transfusion Recipients at a Teaching Hospital in Lahore, Pakistan.Cureus · 2022Article
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundBlood transfusion is one of the most common medical procedures during hospitalization in the United States. To understand the benefits of transfusion while mitigating potential risks, a multicenter database containing detailed information on transfusion incidence and recipient outcomes would facilitate research. STUDY DESIGN AND
methodsThe Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) program has developed a comprehensive transfusion recipient database utilizing data from hospital electronic health records at 12 participating hospitals in four geographic regions. Inpatient and outpatient data on transfusion recipients from January 1, 2013 to December 31, 2014 included patient age, sex, ethnicity, primary diagnosis, type of blood product provided, issue location, pretransfusion and post-transfusion hemoglobin (Hgb), and hospital outcomes. Transfusion incidence per encounter was calculated by blood product and various patient characteristics.
resultsDuring the 2-year study period, 80,362 (12.5%) inpatient encounters involved transfusion. Among inpatients, the most commonly transfused blood products were red blood cells (RBCs; 10.9% of encounters), followed by platelets (3.2%) and plasma (2.9%). Among patients who received transfusions, the median number of RBC units was one, the pretransfusion Hgb level was 7.6 g/dL, and the Hgb increment per unit was 1.4 g/dL. Encounter mortality increased with patient age, the number of units transfused, and the use of platelet or plasma products. The most commonly reported transfusion reaction was febrile nonhemolytic.
conclusionThe database contains comprehensive data regarding transfusion use and patient outcomes. The current report describes an evaluation of the first 2 years of a planned, 4-year, linked blood donor-component-recipient database, which represents a critical new resource for transfusion medicine researchers.
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