ArticleEndocrine2017
Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function-observations from a community-based program.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies.BMC endocrine disorders · 2021Pooled it
- The association between vitamin D and hypothyroidism: a systematic review and meta-analysis.Nutrition & metabolism · 2026Review
- The Role of Vitamin D in Autoimmune Thyroid Diseases: From Immunomodulation to Clinical Implications.Nutrients · 2026Review
- Genetically Predicted 25-Hydroxyvitamin D Levels on Hypothyroidism: A Two-Sample Mendelian Randomization.BioMed research international · 2026Article
- Vitamin D as a central modulator of thyroid diseases: mechanisms and clinical implications.Frontiers in immunology · 2026Review
- Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Serum Vitamin D Levels in Autoimmune and Non-Autoimmune Hypothyroidism: A Retrospective Study from Jordan.Avicenna journal of medicine · 2025Article
- Association of micronutrient status with thyroid function in adolescent Afghan refugees; a cross-sectional study.Thyroid research · 2025Article
- Relationship between thyroid-stimulating hormone levels and the severity of vitamin D deficiency by age group.Clinical and experimental reproductive medicine · 2025Article
- Correlation Between Vitamin D and TSH Levels in Healthy Controls and Individuals with Hypothyroidism According to Age and Sex.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025Article
- Autoimmune Thyroiditis and Vitamin D.International journal of molecular sciences · 2024Review
- Article
- The mediating role of serum 25-hydroxyvitamin D on the association between reduced sensitivity to thyroid hormones and periodontitis in Chinese euthyroid adults.Frontiers in endocrinology · 2024Article
- Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults.Nutrients · 2023Article
- Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice.Nutrients · 2023Review
- Article
- The Effect of Vitamin D Adequacy on Thyroid Hormones and Inflammatory Markers after Bariatric Surgery.Metabolites · 2023Article
- The Role of Vitamin D in Autoimmune Thyroid Diseases: A Narrative Review.Journal of clinical medicine · 2023Review
- Vitamin D and the Thyroid: A Critical Review of the Current Evidence.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVitamin D deficiency has been associated with an increased risk of hypothyroidism and autoimmune thyroid disease. Our aim was to investigate the influence of vitamin D supplementation on thyroid function and anti-thyroid antibody levels.
methodsWe constructed a database that included 11,017 participants in a health and wellness program that provided vitamin D supplementation to target physiological serum 25-hydroxyvitmain D [25(OH)D] concentrations (>100 nmol/L). Participant measures were compared between entry to the program (baseline) and follow-up (12 ± 3 months later) using an intent-to-treat analysis. Further, a nested case-control design was utilized to examine differences in thyroid function over 1 year in hypothyroid individuals and euthyroid controls.
resultsMore than 72% of participants achieved serum 25(OH)D concentrations >100 nmol/L at follow-up, with 20% above 125 nmol/L. Hypothyroidism was detected in 2% (23% including subclinical hypothyroidism) of participants at baseline and 0.4% (or 6% with subclinical) at follow-up. Serum 25(OH)D concentrations ≥125 nmol/L were associated with a 30% reduced risk of hypothyroidism and a 32% reduced risk of elevated anti-thyroid antibodies. Hypothyroid cases were found to have higher mean serum 25(OH)D concentrations at follow-up, which was a significant positive predictor of improved thyroid function.
conclusionThe results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.