Evidence map›Paper›PMID 29067569›Full record

ArticleNanoscale research letters2017

Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels.

Jinyu Wang, Weibo Zhao, Haixiao Chen, An Qin, Peizhi Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jinyu WangCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225200, Jiangsu, People's Republic of China.
Weibo ZhaoOrthopaedic Department, Taizhou Hospital, Wenzhou Medical University, Taizhou, 318000, Zhejiang, People's Republic of China.
Haixiao ChenOrthopaedic Department, Taizhou Hospital, Wenzhou Medical University, Taizhou, 318000, Zhejiang, People's Republic of China. drchx@126.com.
An QinDepartment of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peizhi ZhuCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225200, Jiangsu, People's Republic of China. pzzhu@yzu.edu.cn.
Wenzhou Medical University · CNYangzhou University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.

Indexed as

Anti-tumorChondroitin sulfateMethotrexateNanogelsNanomedicineNanotechnologySelf-assembly

Identifiers

PMID29067569
PMCPMC5655378
OpenAlexW2766673351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.