Evidence map›Paper›PMID 29067547›Full record

ArticleAnnals of nuclear medicine2018

Low levels of PSMA expression limit the utility of

Scott P Campbell, Alexander S Baras, Mark W Ball, Max Kates, Noah M Hahn, Trinity J Bivalacqua, Michael H Johnson, Martin G Pomper, Mohamad E Allaf, Steven P Rowe and 1 more

Open access · greenAbstract read
In one paragraph

Article in Annals of nuclear medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Comparison of [Molecular imaging and biology · 2026
    Article
  5. Review
  6. Article
  7. Head-to-head comparisons ofInternational urology and nephrology · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Feasibility of [European journal of nuclear medicine and molecular imaging · 2022
    Article
  12. PSMA expression on neovasculature of solid tumors.Histology and histopathology · 2020
    Review
  13. Review
  14. Article
  15. The use ofEuropean journal of nuclear medicine and molecular imaging · 2019
    Article
  16. Article
  17. Antibody-Drug Conjugates in Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Scott P CampbellThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander S BarasDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mark W BallThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Max KatesThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noah M HahnDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Trinity J BivalacquaThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael H JohnsonThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Martin G PomperThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mohamad E AllafThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven P RoweThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael A GorinThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mgorin1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
PSMA Directed Imaging of Prostate Cancer Focus on Androgen Receptor DynamicsU01CA183031 · NCI · JOHNS HOPKINS UNIVERSITY · PI DEWEESE, THEODORE L, POMPER, MARTIN G · 2015 to 2017
$1.2M
Molecular Analysis and Precision Medicine in Renal Cell CarcinomaK01ES026838 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, MICHAEL HIROSHI · 2015 to 2019
$821k
National Institutes of Health CA134675National Institutes of Health CA183031NCI NIH HHS R01 CA134675NCI NIH HHS U01 CA183031NIEHS NIH HHS K01 ES026838
6 · The paper itself

Abstract

objectiveTo explore the clinical utility of PSMA-targeted

methodsThree patients with metastatic urothelial carcinoma were imaged with

results

conclusionThe relatively scant expression of PSMA by urothelial carcinoma likely limits the utility of PSMA-targeted PET imaging of this malignancy. Future research efforts should focus on the development of other molecularly targeted imaging agents for urothelial carcinoma.

Indexed as

Gene Expression Regulation, NeoplasticPositron Emission Tomography Computed TomographyUrotheliumAgedAntigens, SurfaceGlutamate Carboxypeptidase IIHumansLysineMaleMiddle AgedUreaUrologic Neoplasms2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILysineUrea18F-DCFPyL PET/CTBladder cancerProstate-specific membrane antigenPSMATransitional cell carcinomaUrothelial carcinoma

Identifiers

PMID29067547
PMCPMC5881395
OpenAlexW2765299895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.