Evidence map›Paper›PMID 29067356›Full record

ArticleeNeuro

Cell-Specific RNA Binding Protein Rbfox2 Regulates Ca

Summer E Allen, Cecilia P Toro, Arturo Andrade, Eduardo J López-Soto, Sylvia Denome, Diane Lipscombe

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. ApoER2: Functional Tuning Through Splicing.Frontiers in molecular neuroscience · 2020
    Review
  8. Article
  9. Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Summer E AllenDepartment of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912.ORCID 0000-0002-8219-6750
Cecilia P ToroDepartment of Biology, Linfield College, McMinnville, OR 97128.ORCID 0000-0003-2241-432X
Arturo AndradeDepartment of Biological Sciences, University of New Hampshire, Durham, NH 03824.ORCID 0000-0001-6585-2413
Eduardo J López-SotoDepartment of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912.ORCID 0000-0003-3298-8001
Sylvia DenomeDepartment of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912.ORCID 0000-0002-9888-0979
Diane LipscombeDepartment of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912.ORCID 0000-0002-7146-9119
Allen Institute for Brain Science · USLinfield College · USUniversity of New Hampshire · US

Funding

Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety BehaviorR00MH099405 · NIMH · UNIVERSITY OF NEW HAMPSHIRE · PI ANDRADE, ARTURO · 2015 to 2017
$738k
Finding factors that control cell-specific splicing of a calcium channelF31NS066691 · NINDS · BROWN UNIVERSITY · PI ALLEN, SUMMER ELIZABETH · 2009 to 2011
$61k
Does alternative splicing regulate G protein inhibition of calcium channels?F31NS066712 · NINDS · BROWN UNIVERSITY · PI TORO, CECILIA PHILLIPS · 2010 to 2011
$57k
NIMH NIH HHS R00 MH099405NINDS NIH HHS F31 NS066691NINDS NIH HHS F31 NS066712NINDS NIH HHS R01 NS055251
6 · The paper itself

Abstract

The majority of multiexon mammalian genes contain alternatively spliced exons that have unique expression patterns in different cell populations and that have important cell functions. The expression profiles of alternative exons are controlled by cell-specific splicing factors that can promote exon inclusion or exon skipping but with few exceptions we do not know which specific splicing factors control the expression of alternatively spliced exons of known biological function. Many ion channel genes undergo extensive alternative splicing including

Indexed as

Action PotentialsAnimalsAnimals, NewbornCalcium Channels, N-TypeCells, CulturedExonsFemaleGene Expression Regulation, DevelopmentalHumansMaleMiceMice, Inbred C57BLMice, TransgenicModels, MolecularNeuronsRatsCacna1b protein, mouseCalcium Channels, N-TypeRbfox2 protein, mouseRNA, MessengerRNA, Small InterferingRNA Splicing Factorsalternative splicingcalcium channelsN-typerbfox2splicing factorssuperior cervical ganglia

Identifiers

PMID29067356
PMCPMC5633781
OpenAlexW2759819776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.