ArticleAlzheimer's & dementia (New York, N. Y.)2017
Determining the impact of psychosis on rates of false-positive and false-negative diagnosis in Alzheimer's disease.
Article in Alzheimer's & dementia (New York, N. Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Utility of Addenbrooke's Cognitive Examination III (ACE-III) in Differentiating Neurodegenerative Disorders with Psychotic Symptoms: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Alzheimer's disease diagnosis support for brain perfusion SPECT scans in a real-world clinical cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Clinical Evolution of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies in a Post-Mortem Cohort.International journal of geriatric psychiatry · 2025Article
- Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle.Acta neuropathologica communications · 2025Article
- Introduction to Large Language Models (LLMs) for dementia care and research.Frontiers in dementia · 2024Article
- Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review.Journal of geriatric psychiatry and neurology · 2023Review
- Five-year trend of antipsychotic prescription practices in a district Hospital in Ghana: A retrospective study.Neuropsychopharmacology reports · 2023Article
- Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities.Nature reviews. Neurology · 2022Review
- Characteristics Scanning of Brain Structure and Function Changes in Patients with Different Degrees of Alzheimer's Disease.Contrast media & molecular imaging · 2022Article
- Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology.Scientific reports · 2019Article
- Challenges of Integrative Disease Modeling in Alzheimer's Disease.Frontiers in molecular biosciences · 2019Review
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Review
- Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease.Current Alzheimer research · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
introductionThe rate of clinical misdiagnosis of Alzheimer's disease (AD) and how psychosis impacts that clinical judgment is unclear.
methodsUsing data from National Alzheimer's Coordinating Center, we compared the clinical and neuropathologic diagnosis in patients with a diagnosis of AD with autopsy and in neuropathology-confirmed AD cases (
resultsA total of 76% received a correct AD diagnosis, 11.9% had a false-negative diagnosis, and 12.1% had a false-positive diagnosis of AD. Psychotic patients had a higher rate of false-negative diagnosis and a lower rate of false-positive diagnosis of AD compared with nonpsychotic patients. DISCUSSION: Patients with psychosis were five times more likely to be misdiagnosed as dementia with Lewy bodies, whereas patients without psychosis were more likely to be falsely diagnosed with AD when vascular pathology is the underlying neuropathologic cause of dementia.
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