ArticleAlzheimer's & dementia (New York, N. Y.)2017
Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment.
Article in Alzheimer's & dementia (New York, N. Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise.Scientific reports · 2021Trial
- The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial.Cerebral circulation - cognition and behavior · 2025Article
- Exploring the associations of daily movement behaviours and mid-life cognition: a compositional analysis of the 1970 British Cohort Study.Journal of epidemiology and community health · 2023Article
- Influence of Aerobic Exercise Load Intensity on Children's Mental Health.Emergency medicine international · 2022Article
- Dutch Brain Research Registry for study participant recruitment: Design and first results.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Heart Failure and Cognitive Impairment: Clinical Relevance and Therapeutic Considerations.Current cardiology reviews · 2019Review
- Exercise Improves Vascular Function, but does this Translate to the Brain?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Cognitive Deficits in Multiple Sclerosis: Recent Advances in Treatment and Neurorehabilitation.Current treatment options in neurology · 2018Review
- Amsterdam Dementia Cohort: Performing Research to Optimize Care.Journal of Alzheimer's disease : JAD · 2018Review
- The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study.Cerebrovascular diseases extra · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.