Evidence map›Paper›PMID 29067293›Full record

ReviewAlzheimer's & dementia (New York, N. Y.)2016

Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia.

Larry Alphs, H Robert Brashear, Phillip Chappell, Yeates Conwell, Sarah Dubrava, Ni A Khin, Nicholas Kozauer, Dean M Hartley, David S Miller, Rachel J Schindler and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia (New York, N. Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Care for Older People with Dementia During COVID-19 Pandemic.SN comprehensive clinical medicine · 2021
    Review
  8. Review
  9. Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer's Disease and Related Dementias.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Larry AlphsJanssen Scientific Affairs, LLC, Titusville, NJ, USA.
H Robert BrashearJanssen Alzheimer Immunotherapy & Research & Development, LLC, South San Francisco, CA, USA.
Phillip ChappellPfizer, Groton, CT, USA.
Yeates ConwellUniversity of Rochester, Rochester, NY, USA.
Sarah DubravaPfizer, Groton, CT, USA.
Ni A KhinDivision of Psychiatry Products, Food and Drug Administration, Silver Spring, MD, USA.
Nicholas KozauerDivision of Neurology Products, Food and Drug Administration, Silver Spring, MD, USA.
Dean M HartleyAlzheimer's Association, Chicago, IL, USA.
David S MillerBracket, Wayne, PA, USA.
Rachel J SchindlerPfizer, Inc., New York, NY, USA.
Eric R SiemersEli Lilly and Company, Inc., Indianapolis, IN, USA.
Michelle StewartPfizer, Groton, CT, USA.
Kristine YaffeUniversity of California, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBetter understanding of suicide risk and its management in older adults with cognitive impairment and/or dementia remain significant unmet public health needs. Urgency to address them derives from concern that CNS treatments for dementia may impact suicide risk. Regulatory guidances requiring assessment of emergent suicidal ideation and behavior (SI/SB) at every clinical trial visit emphasize the need for understanding their prevalence.

methodsThe literature regarding SI/SB in older persons with cognitive impairment or dementia was reviewed by an Alzheimer's Association Taskforce with emphasis on epidemiology, classification, assessment, and regulatory requirements.

resultsGaps in our knowledge were identified, challenges discussed and recommendations for future work provided. DISCUSSION: Currently available SI/SB data from geriatric persons with dementia do not provide adequate understanding of its epidemiology, identification, assessment, or management. The growing public health burden of this population requires greater attention from clinicians and researchers on tactics and assessment tools to meet these needs.

Indexed as

Cognitive impairmentDementiaElderlySuicidal behaviorSuicidal ideationSuicidalitySuicideSuicide assessmentSuicide risk

Identifiers

PMID29067293
PMCPMC5644272

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.