ArticleJournal of clinical & translational endocrinology2017
Prognostic indicators for the development of strabismus among patients with graves' ophthalmopathy.
Article in Journal of clinical & translational endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Etiology and Clinical Features of Diplopia in South China: Analysis of 303 Cases.Frontiers in neurology · 2021Article
- Thyroid autoantibodies in adults with acquired binocular diplopia of unknown origin.Scientific reports · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThyroid eye disease (TED), an autoimmune inflammatory process involving the orbital tissues around the eye, is the most common extra-thyroidal manifestation of Graves' disease (GD). Due to changes in the patient's appearance, TED is a socially and visually disabling condition with significant impacts on quality of life. The aim of this study is to assess predictors of strabismus, a severe manifestation of TED.
designSingle-institution retrospective case-control study. Cases of Graves' ophthalmopathy patients with strabismus were matched 1:1 to controls of Graves' ophthalmopathy patients without strabismus by age and sex. PATIENTS: Patients ≥18 years old with severe Graves' ophthalmopathy who received their medical care at UCLA with strabismus between 2012 and 2015. MEASUREMENTS: Eligibility criteria for cases was a diagnosis of Graves' ophthalmopathy with a subsequent diagnosis of strabismus. Using conditional logistic regression, the odds ratios of developing strabismus following the diagnosis of Graves' disease were assessed. The prognostic indicators assessed include race, ethnicity, cigarette smoking (active), serum thyroid peroxidase (TPO) antibody positivity, serum thyroglobulin (Tg) antibody positivity, antithyroidal medication use, and steroid use.
resultsThe study sample (45 cases 1:1 matched against 45 controls) was comprised primarily of non-Hispanic, non-Latino Caucasian women with TED (mean ± SD age 63.0 ± 13.1 years). There were no significant predictors for the development of strabismus, including cigarette smoking (active), serum thyroid peroxidase (TPO) antibody positivity, serum thyroglobulin (Tg) antibody positivity, antithyroidal medication, and steroid use.
conclusionsNo significant predictors of strabismus, a severe manifestation of Graves' ophthalmopathy, were identified following a diagnosis of TED in this study.
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