ReviewJournal of clinical & translational endocrinology2016
Benign thyroid disease in pregnancy: A state of the art review.
Review in Journal of clinical & translational endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.BMC pregnancy and childbirth · 2022Trial
- Maternal thyroid function in the first half of pregnancy and neurodevelopmental outcomes in early adolescence in the Amsterdam Born Children and their Development (ABCD) cohort.Comprehensive psychoneuroendocrinology · 2026Article
- Hypothyroidism monitoring and control during the first trimester of pregnancy in Catalonia.Frontiers in endocrinology · 2025Article
- Review
- Description of thyroid disorders the year before conception: a population-based study.Frontiers in endocrinology · 2023Article
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- The role of transforming growth factor beta in thyroid autoimmunity: current knowledge and future perspectives.Reviews in endocrine & metabolic disorders · 2022Review
- Excessive Gestational Weight Gain and Long-Term Maternal Cardiovascular Risk Profile: The Study of Women's Health Across the Nation.Journal of women's health (2002) · 2022Article
- Sex bias in lymphocytes: Implications for autoimmune diseases.Frontiers in immunology · 2022Review
- OctylPhenol (OP) Alone and in Combination with NonylPhenol (NP) Alters the Structure and the Function of Thyroid Gland of the Lizard Podarcis siculus.Archives of environmental contamination and toxicology · 2021Article
- Pregnancy-induced increased heart rate is independent of thyroid hormones.Heart rhythm O2 · 2021Article
- Gestational Weight Gain and Long-term Maternal Obesity Risk: A Multiple-Bias Analysis.Epidemiology (Cambridge, Mass.) · 2021Article
- Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study.BMC pregnancy and childbirth · 2020Article
- Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition.Archives of endocrinology and metabolism · 2020Review
- Thyroid disorders in subfertility and early pregnancy.Therapeutic advances in endocrinology and metabolism · 2020Review
- Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis.Human brain mapping · 2019Review
- A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.Environmental health : a global access science source · 2019Article
- Article
- Risk factors for adverse maternal and perinatal outcomes in women with preeclampsia: analysis of 1396 cases.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.Environment international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other. Overt hypothyroidism and hyperthyroidism should be treated appropriately in pregnancy, aiming to maintain euthyroidism. Subclinical hypothyroidism is often pragmatically treated with levothyroxine, although it has not been definitively proven whether this alters maternal or fetal outcomes. Subclinical hyperthyroidism does not usually require treatment and the possibility of non-thyroidal illness or gestational thyrotoxicosis should be considered. Autoimmune thyroid diseases tend to improve during pregnancy but commonly flare-up or emerge in the post-partum period. Accordingly, thyroid auto-antibodies tend to decrease with pregnancy progression. Postpartum thyroiditis should be managed based on the clinical symptoms rather than abnormal biochemical results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.