ArticleCognitive neurodynamics2017
Right cerebral hemispheric sensitivity to pH and physiological ions in fixed post-mortem Wistar rat brains.
Article in Cognitive neurodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Post-mortem human neural tissues fixed in ethanol and aldehyde-based solutions express modulated frequency-dependent microvolt potentials when probed by chemical and electrical stimuli. These observations run contrary to the assumption that basic tissue functions are irreversibly impaired upon fixation, in the absence of nutrients and sufficient concentrations of physiological ions. The aim of the current study was to investigate the relative effects of pH and specific charged particles relevant to normal cell physiology upon electric potentials associated with fixed post-mortem rat brain tissue. We identified a positive relationship between the total time the brains had been immersed in ethanol-formalin-acetic acid and high-frequency microvolt potentials within the dorsal right hemisphere of the rat cerebrum. Measuring the pH of the fixative solution surrounding the brains indicated that as time increased, a logarithmic trend toward alkalinity could be observed. Further experiments revealed that high-frequency microvolt potentials were related to pH changes within the right hemisphere only. The right ventral cerebrum displayed a unique response to potassium chloride in ways uncounted for by pH alone. The results suggest that the fixed post-mortem right cerebrum of the rat is particularly sensitive to pH and physiological ions which explains a subset of previous findings with respect to stimulus-response patterns in human coronal brain sections. A concluding hypothesis is presented which suggests that brain tissue expresses material properties independent of metabolic activity though perhaps relevant to living brain function.
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