ReviewFrontiers in neuroscience2017
Biomarkers and Stimulation Algorithms for Adaptive Brain Stimulation.
Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cellular, molecular, and clinical mechanisms of action of deep brain stimulation-a systematic review on established indications and outlook on future developments.EMBO molecular medicine · 2019Pooled it
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Continuous Accelerometry-Based Tremor Detection During Daily Living.Sensors (Basel, Switzerland) · 2026Article
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- At home adaptive dual target deep brain stimulation in Parkinson's disease with proportional control.Brain : a journal of neurology · 2024Article
- Multimodal subspace identification for modeling discrete-continuous spiking and field potential population activity.Journal of neural engineering · 2024Article
- Development and Evaluation of a Real-Time Phase-Triggered Stimulation Algorithm for the CorTec Brain Interchange.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Closed-loop modulation of model parkinsonian beta oscillations based on CAR-fuzzy control algorithm.Cognitive neurodynamics · 2023Article
- Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice.Journal of visualized experiments : JoVE · 2023Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Modeling multiscale causal interactions between spiking and field potential signals during behavior.Journal of neural engineering · 2022Article
- Personalised Advanced Therapies in Parkinson's Disease: The Role of Non-Motor Symptoms Profile.Journal of personalized medicine · 2021Article
- Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation.Nature biomedical engineering · 2021Article
- Methods for Lowering the Power Consumption of OS-Based Adaptive Deep Brain Stimulation Controllers.Sensors (Basel, Switzerland) · 2021Article
- Phase-Dependent Deep Brain Stimulation: A Review.Brain sciences · 2021Review
- Bilateral Intracranial Beta Activity During Forced and Spontaneous Movements in a 6-OHDA Hemi-PD Rat Model.Frontiers in neuroscience · 2021Article
- Suppression and Rebound of Pallidal Beta Power: Observation Using a Chronic Sensing DBS Device.Frontiers in human neuroscience · 2021Article
- Adaptive Parameter Modulation of Deep Brain Stimulation Based on Improved Supervisory Algorithm.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The goal of this review is to describe in what ways feedback or adaptive stimulation may be delivered and adjusted based on relevant biomarkers. Specific treatment mechanisms underlying therapeutic brain stimulation remain unclear, in spite of the demonstrated efficacy in a number of nervous system diseases. Brain stimulation appears to exert widespread influence over specific neural networks that are relevant to specific disease entities. In awake patients, activation or suppression of these neural networks can be assessed by either symptom alleviation (i.e., tremor, rigidity, seizures) or physiological criteria, which may be predictive of expected symptomatic treatment. Secondary verification of network activation through specific biomarkers that are linked to symptomatic disease improvement may be useful for several reasons. For example, these biomarkers could aid optimal intraoperative localization, possibly improve efficacy or efficiency (i.e., reduced power needs), and provide long-term adaptive automatic adjustment of stimulation parameters. Possible biomarkers for use in portable or implanted devices span from ongoing physiological brain activity, evoked local field potentials (LFPs), and intermittent pathological activity, to wearable devices, biochemical, blood flow, optical, or magnetic resonance imaging (MRI) changes, temperature changes, or optogenetic signals. First, however, potential biomarkers must be correlated directly with symptom or disease treatment and network activation. Although numerous biomarkers are under consideration for a variety of stimulation indications the feasibility of these approaches has yet to be fully determined. Particularly, there are critical questions whether the use of adaptive systems can improve efficacy over continuous stimulation, facilitate adjustment of stimulation interventions and improve our understanding of the role of abnormal network function in disease mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.