ArticleJournal of pain research2017
The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Antidepressants for hip and knee osteoarthritis.The Cochrane database of systematic reviews · 2022Pooled it
- Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis.The Korean journal of internal medicine · 2019Pooled it
- Neuropathic-like pain symptoms in inflammatory hand osteoarthritis lower quality of life and may not decrease under prednisolone treatment.European journal of pain (London, England) · 2022Trial
- Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis.Clinical rheumatology · 2019Trial
- Reduced anterior cingulate grey matter volume in painful hand osteoarthritis.Rheumatology international · 2018Trial
- Mixed pain phenotypes in musculoskeletal disorders: mechanisms and management.Nature reviews. Rheumatology · 2026Review
- A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee.Osteoarthritis and cartilage open · 2026Article
- Navigating the Efficacy and Safety Landscape of Duloxetine in Osteoarthritis Management: A Meta-Analysis of Randomized Controlled Trials.Indian journal of orthopaedics · 2025Review
- Psychotropic Drug Use in Korean Patients With Osteoarthritis.Journal of Korean medical science · 2025Article
- Neuropathic pain in knee osteoarthritis: Prevalence, diagnosis, and clinical implications.Joint diseases and related surgery · 2025Article
- Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis.Journal of pain research · 2025Article
- Translational validity of quantitative sensory testing in chronic pain neuro-sensitization: guide of use and interpretation in osteoarthritis animal models.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Current and future advances in practice: practical management of hand osteoarthritis.Rheumatology advances in practice · 2025Review
- Grip Strength Impairment and Neuropathic-Like Pain as Predictors of Functional Decline in Hand Osteoarthritis.Open access rheumatology : research and reviews · 2025Article
- Uncoupling the CRMP2-CaThe journal of pain · 2024Article
- Uncoupling the CRMP2-CabioRxiv : the preprint server for biology · 2024Article
- Report of similar placebo response in one internet versus onsite randomised controlled trials from the literature.Osteoarthritis and cartilage open · 2024Article
- Assessment of Neuropathic Pain in Erosive Hand Osteoarthritis.Journal of clinical medicine · 2024Article
- Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study.Osteoarthritis and cartilage · 2023Article
- Antidepressants for pain management in adults with chronic pain: a network meta-analysis.The Cochrane database of systematic reviews · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 years, with a Numerical Rating Scale (NRS) for pain of at least 5. Participants were randomized to one of the following three groups: duloxetine, pregabalin, and placebo. The primary endpoint was the NRS pain score, and the secondary endpoints included the Australian and Canadian Hand Osteoarthritis Index (AUSCAN) pain, stiffness, and function scores and quantitative sensory testing by pain pressure algometry. After 13 weeks, compared to placebo, ANOVA found significant differences between the three groups (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.