Evidence map›Paper›PMID 29066872›Full record

ArticleClinical interventions in aging2017

Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China.

Zheng Xia, Yazhuo Hu, Zhitao Han, Ya Gao, Jie Bai, Yao He, Hua Zhao, Honghong Zhang

Open access · goldAbstract read
In one paragraph

Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Journal of diabetes and metabolic disorders · 2021
    Review
  8. Article
  9. Diminished 25-OH vitamin DJournal of clinical laboratory analysis · 2020
    Article
  10. Article
  11. Biomedical reports · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zheng Xia *Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Yazhuo Hu *Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Zhitao HanInstitute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Ya GaoInstitute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Jie BaiCinical Laboratory in South Building, Chinese PLA General Hospital & Chinese PLA Medical Academy, Beijing, China.
Yao HeInstitute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Hua ZhaoZhantansi Outpatient Department, Chinese PLA 309 Hospital, Beijing, China.
Honghong ZhangInstitute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
Beijing Geriatric Hospital · CNChinese PLA General Hospital · CNPLA 306 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China.

methodsA total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing. The frequency and distribution of the SNPs were compared between cases and controls.

resultsThe distribution of genotypes of VDR-FokI was significantly different between the control and DM group (

conclusionThese findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China.

Indexed as

Polymorphism, Single NucleotideAgedAllelesCase-Control StudiesChinaDiabetes Mellitus, Type 2DyslipidemiasFemaleGene FrequencyGenotypeHumansMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthReceptors, CalcitriolReceptors, CalcitriolVDR protein, humandiabetesdyslipidemiaelderlypolymorphismVDRvitamin D receptor

Identifiers

PMID29066872
PMCPMC5644535
OpenAlexW2762068422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.