ArticleScientific reports2017
Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- The Acceptance, Commitment and COgnitive RemeDiation (ACCORD) Study: Can a Brief Online Cognitive Intervention Improve Outcomes in Patients With Esophageal Disease?Neurogastroenterology and motility · 2025Article
- Revealing the different levels of action monitoring in visuomotor transformation task: Evidence from decomposition of cortical potentials.Psychophysiology · 2025Article
- Motor, mood, and memory impairments persist during remission periods in chronic colitis and are influenced by neuroinflammation and sex.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Aperiodic neural activity reflects metacontrol in task-switching.Scientific reports · 2024Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- The influence of bilingual experience on executive function under emotional interference: Evidence from the N1 component.Frontiers in psychology · 2023Article
- Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis.Frontiers in immunology · 2023Article
- An examination of resting-state functional connectivity in patients with active Crohn's disease.Frontiers in neuroscience · 2023Article
- Protocol to decode representations from EEG data with intermixed signals using temporal signal decomposition and multivariate pattern-analysis.STAR protocols · 2022Article
- Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits.International journal of molecular sciences · 2022Article
- Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice.The American journal of pathology · 2022Article
- Gastrointestinal Changes and Alzheimer's Disease.Current Alzheimer research · 2022Review
- Multi-level decoding of task sets in neurophysiological data during cognitive flexibility.iScience · 2021Article
- Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD).Molecular psychiatry · 2021Article
- Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits.Journal of neuroinflammation · 2021Article
- Impaired cognitive function in Crohn's disease: Relationship to disease activity.Brain, behavior, & immunity - health · 2020Article
- Impaired neurocognitive and psychomotor performance in patients with inflammatory bowel disease.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is highly prevalent. While the pathophysiological mechanisms of IBD are increasingly understood, there is a lack of knowledge concerning cognitive dysfunctions in IBD. This is all the more the case concerning the underlying neurophysiological mechanisms. In the current study we focus on possible dysfunctions of cognitive flexibility (task switching) processes in IBD patients using a system neurophysiological approach combining event-related potential (ERP) recordings with source localization analyses. We show that there are task switching deficits (i.e. increased switch costs) in IBD patients. The neurophysiological data show that even though the pathophysiology of IBD is diverse and wide-spread, only specific cognitive subprocesses are altered: There was a selective dysfunction at the response selection level (N2 ERP) associated with functional alterations in the anterior cingulate cortex and the right inferior frontal gyrus. Attentional selection processes (N1 ERP), perceptual categorization processes (P1 ERP), or mechanisms related to the flexible implementation of task sets and related working memory processes (P3 ERP) do not contribute to cognitive inflexibility in IBD patients and were unchanged. It seems that pathophysiological processes in IBD strongly compromise cognitive-neurophysiological subprocesses related to fronto-striatal networks. These circuits may become overstrained in IBD when cognitive flexibility is required.
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