ArticleScientific reports2017
Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Risk of Retinopathy Associated with Long-Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta-Analysis.Arthritis care & research · 2026Pooled it
- Vascular Changes in the Macula and Peripapillary Regions Using Optical Coherence Tomography Angiography in Migraine with Aura and Migraine Without Aura.Journal of clinical medicine · 2026Article
- Relationship between Corvis ST tonometry parameters and mean blur rate in the optic nerve head tissue area in healthy eyes.PloS one · 2026Article
- The effect of habitual sitting posture on peripheral retinal alterations.International ophthalmology · 2025Article
- Vascular density normative data of radial peripapillary capillary plexus in healthy Caucasian subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging.Translational vision science & technology · 2024Article
- Novel superpixel method to visualize fundus blood flow resistivity in healthy adults.Scientific reports · 2023Article
- Article
- Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study.The British journal of ophthalmology · 2022Article
- Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease.BioMed research international · 2022Article
- U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects.Investigative ophthalmology & visual science · 2021Article
- Advances in translational imaging of the microcirculation.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation.Scientific reports · 2021Article
- Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head.Translational vision science & technology · 2021Article
- Laser speckle contrast imaging system using nanosecond pulse laser source.Journal of biomedical optics · 2020Article
- Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation.Scientific reports · 2019Article
- Influence of age and gender on the pulse waveform in optic nerve head circulation in healthy men and women.Scientific reports · 2019Article
- The influences of gender and aging on optic nerve head microcirculation in healthy adults.Scientific reports · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex-related differences are present in the systemic and ocular blood flow. However, the cause of the sex-related differences has not been determined. We investigated the ocular blood flow, represented by the mean blur rate (MBR), on the optic nerve head (ONH) determined by laser speckle flowgraphy in 138 males (63.9 ± 8.9 years) and 194 females (63.5 ± 9.4 years). The correlations between the MBR on the ONH and the clinical data were determined. The overall ONH-MBR was significantly higher in females than males (P < 0.001). In addition, the levels of the hemoglobin and hematocrit were significantly lower in females than in males (P < 0.001). The ONH-MBR was negatively and significantly correlated with the levels of the hemoglobin and hematocrit (both, P < 0.001). Multiple regression analyses showed that the sex (β = 0.248, P < 0.001) was an independent factor correlated with the ONH-MBR when the clinical examination data were not included in the analyses. However, when the clinical examination data were included, the hemoglobin level (β = -0.295, P < 0.001) was an independent factor that contributed to the ONH-MBR but the sex was not. We conclude that the sex-related differences in the hemoglobin level and the negative correlation between hemoglobin and the ONH-MBR are the causes of the sex-related differences in the ONH-MBR.
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