ArticleScientific reports2017
Canine dorsal root ganglia satellite glial cells represent an exceptional cell population with astrocytic and oligodendrocytic properties.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy.bioRxiv : the preprint server for biology · 2026Article
- Infection of a β-galactosidase-deficient mouse strain with Theiler's murine encephalomyelitis virus reveals limited immunological dysregulations in this lysosomal storage disease.Frontiers in immunology · 2025Article
- Ultrastructure of dorsal root ganglia.Cell and tissue research · 2023Review
- Ovalbumin-specific CD4Frontiers in immunology · 2023Article
- Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture.Neurochemical research · 2022Article
- Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.Journal of anatomy · 2022Article
- Single-Dose Intrathecal Dorsal Root Ganglia Toxicity of Onasemnogene Abeparvovec in Cynomolgus Monkeys.Human gene therapy · 2022Article
- Morphological and phenotypical characteristics of porcine satellite glial cells of the dorsal root ganglia.Frontiers in neuroanatomy · 2022Article
- Glia from the central and peripheral nervous system are differentially affected by paclitaxel chemotherapyFrontiers in pharmacology · 2022Article
- Phenotypical changes of satellite glial cells in a murine model of GJournal of cellular and molecular medicine · 2022Article
- Article
- Phenotypical peculiarities and species-specific differences of canine and murine satellite glial cells of spinal ganglia.Journal of cellular and molecular medicine · 2021Article
- Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB.Veterinary pathology · 2021Article
- Emerging importance of satellite glia in nervous system function and dysfunction.Nature reviews. Neuroscience · 2020Review
- Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity.Blood advances · 2020Article
- Axonopathy and Reduction of Membrane Resistance: Key Features in a New Murine Model of Human GJournal of clinical medicine · 2020Article
- Neurotrophic effects of GScientific reports · 2020Article
- Compartmentalized Neuronal Culture for Viral Transport Research.Frontiers in microbiology · 2020Review
- Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.Brain and behavior · 2019Article
- Cryopreservation of Canine Primary Dorsal Root Ganglion Neurons and Its Impact upon Susceptibility to Paramyxovirus Infection.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dogs can be used as a translational animal model to close the gap between basic discoveries in rodents and clinical trials in humans. The present study compared the species-specific properties of satellite glial cells (SGCs) of canine and murine dorsal root ganglia (DRG) in situ and in vitro using light microscopy, electron microscopy, and immunostainings. The in situ expression of CNPase, GFAP, and glutamine synthetase (GS) has also been investigated in simian SGCs. In situ, most canine SGCs (>80%) expressed the neural progenitor cell markers nestin and Sox2. CNPase and GFAP were found in most canine and simian but not murine SGCs. GS was detected in 94% of simian and 71% of murine SGCs, whereas only 44% of canine SGCs expressed GS. In vitro, most canine (>84%) and murine (>96%) SGCs expressed CNPase, whereas GFAP expression was differentially affected by culture conditions and varied between 10% and 40%. However, GFAP expression was induced by bone morphogenetic protein 4 in SGCs of both species. Interestingly, canine SGCs also stimulated neurite formation of DRG neurons. These findings indicate that SGCs represent an exceptional, intermediate glial cell population with phenotypical characteristics of oligodendrocytes and astrocytes and might possess intrinsic regenerative capabilities in vivo.
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