ArticleScientific reports2017
Altered physiochemical properties in industrially synthesized ZnO nanoparticles regulate oxidative stress; induce in vivo cytotoxicity in embryonic zebrafish by apoptosis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 101 citations in OpenAlex.
- Mechanistic paradigms of teratogenicity induced by metallic nanoparticles-a mini review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Toxicological impacts of biogenic zinc oxide nanoparticles on blue Parrotfish using multibiomarker assessment.Scientific reports · 2026Article
- Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms.Journal of nanobiotechnology · 2025Review
- Investigation of antibacterial and anticancer activities of biosynthesized metal-doped and undoped zinc oxide nanoparticles.Biotechnology and applied biochemistry · 2025Article
- Experimental and density functional theory studies on some metal oxides and the derived nanoclusters: a comparative effects on human ferritin.Discover nano · 2024Article
- Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.Animals : an open access journal from MDPI · 2023Article
- Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos.International journal of molecular sciences · 2023Article
- Biosynthesis, Characterization, and Augmented Anticancer Activity of ZrOJournal of functional biomaterials · 2023Article
- In vivo cytotoxicity analysis of bioceramic root canal sealers on zebrafish embryo.Journal of dental research, dental clinics, dental prospects · 2023Article
- The translational paradigm of nanobiomaterials: Biological chemistry to modern applications.Materials today. Bio · 2022Review
- Nanoparticle Effects on Stress Response Pathways and Nanoparticle-Protein Interactions.International journal of molecular sciences · 2022Review
- Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis.ACS omega · 2022Article
- Phototoxicity effects of NIR-irradiated cesium tungsten oxide (CsToxicology reports · 2022Article
- In-vivo (International journal of nanomedicine · 2022Article
- Effects of Metal Oxide Nanoparticles in Zebrafish.Oxidative medicine and cellular longevity · 2022Review
- Altered electrochemical properties of iron oxide nanoparticles by carbon enhance molecular biocompatibility through discrepant atomic interaction.Materials today. Bio · 2021Article
- Cell-biological effects of zinc oxide spheres and rods from the nano- to the microscale at sub-toxic levels.Cell biology and toxicology · 2021Article
- Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized FromFrontiers in bioengineering and biotechnology · 2021Article
- Selenium and Zinc Oxide Multinutrient Supplementation Enhanced Growth Performance in Zebra Fish by Modulating Oxidative Stress and Growth-Related Gene Expression.Frontiers in bioengineering and biotechnology · 2021Article
- SnOInternational journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the in vivo cytotoxicity of ZnO nanoparticles synthesized at industrial scale with embryonic Zebrafish. Industrial synthesis of ZnO nanoparticles was mimicked at lab scale by high energy ball milling technique by milling bulk ZnO particles for 15 h. Synthesized 7 h and 10 h ZnO nanoparticles showed significant alteration of size, zeta potential and optical properties in comparison to Bulk ZnO. Mortality and hatching rate in Zebrafish embryos were influenced by these alterations. Size and charge dependent effect of ZnO nanoparticles exposure on physiology and development of Zebrafish embryos were evident by malfunctioned organ development and abnormal heartbeat rate. Similar dependency on quenching of ROS due to influential hydrogen bond interaction with glycine residue of Sod1 oxidative stress protein and increased apoptosis were observed in cells. The study revealed the mechanism of cytotoxicity in exposed embryonic Zebrafish as an effect of accumulation and internalization inside cells instigating to generation of hypoxic condition and interference with the normal adaptive stress regulation signaling pathways leading towards enhanced apoptosis. The study revealed hidden size and charge dependent in vivo cytotoxicity mechanism of ZnO nanoparticles in Zebrafish embryos insight of the environmental and clinical importance of attention on industrially synthesized ZnO nanoparticles.
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