ArticleScientific reports2017
Functional classification of protein toxins as a basis for bioinformatic screening.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Universal strategy to generate lentiviral vectors encoding lethal proteins.Molecular therapy. Advances · 2026Article
- Comparative Label-Based Proteomics of Venoms fromProteomes · 2025Article
- Risk analysis approaches for microbial ingredients in microbial-based cleaning products.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- ToxiPep: Peptide toxicity prediction via fusion of context-aware representation and atomic-level graph.Computational and structural biotechnology journal · 2025Article
- ToxDL 2.0: Protein toxicity prediction using a pretrained language model and graph neural networks.Computational and structural biotechnology journal · 2025Article
- VISH-Pred: an ensemble of fine-tuned ESM models for protein toxicity prediction.Briefings in bioinformatics · 2024Article
- In Silico-Based Design of a Hybrid Peptide with Antimicrobial Activity against Multidrug-ResistantToxins · 2023Article
- Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria.Malaria journal · 2023Article
- The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era.International health · 2023Article
- PathFams: statistical detection of pathogen-associated protein domains.BMC genomics · 2021Article
- Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi.Microbial genomics · 2021Article
- Quantum Dots as Biosensors in the Determination of Biochemical Parameters in Xenobiotic Exposure and Toxins.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Review
- Article
- Proteomic Analysis of the Venom of JellyfishesMarine drugs · 2020Article
- Repurposing approved drugs on the pathway to novel therapies.Medicinal research reviews · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Proteins are fundamental to life and exhibit a wide diversity of activities, some of which are toxic. Therefore, assessing whether a specific protein is safe for consumption in foods and feeds is critical. Simple BLAST searches may reveal homology to a known toxin, when in fact the protein may pose no real danger. Another challenge to answer this question is the lack of curated databases with a representative set of experimentally validated toxins. Here we have systematically analyzed over 10,000 manually curated toxin sequences using sequence clustering, network analysis, and protein domain classification. We also developed a functional sequence signature method to distinguish toxic from non-toxic proteins. The current database, combined with motif analysis, can be used by researchers and regulators in a hazard screening capacity to assess the potential of a protein to be toxic at early stages of development. Identifying key signatures of toxicity can also aid in redesigning proteins, so as to maintain their desirable functions while reducing the risk of potential health hazards.
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Registered trials
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