Evidence map›Paper›PMID 29066730›Full record

ArticleScientific reports2017

Neutrophil-lymphocyte Ratio Plus Prognostic Nutritional Index Predicts the Outcomes of Patients with Unresectable Hepatocellular Carcinoma After Transarterial Chemoembolization.

Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Guo-Jun Zeng, Li Jiang, Jian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang LiuDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Lei LiDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wu-Sheng LuDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China. luwu8@126.com.
Hua DuDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Lu-Nan YanDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jia-Yin YangDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tian-Fu WenDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Guo-Jun ZengDepartment of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Li JiangDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jian YangDepartment of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed. A receiver-operating characteristic (ROC) analysis was used to classify patients as follows: NLR-PNI 0 group (NLR ≤ 2.2 and PNI > 46), NLR-PNI 1 group (NLR > 2.2 or PNI ≤ 46) and NLR-PNI 2 group (NLR > 2.2 and PNI ≤ 46). Regarding 1-, 3-, and 5-year survival, the NLR-PNI score had superior discriminative abilities (i.e., higher area under the ROC curve), compared with either the NLR or PNI alone, and patients in the NLR-PNI 0, 1, and 2 groups had median survival times of 33 (95% confidence interval: 22.8-43.2), 14 (10.9-17.1), and 6 (9.9-14.1) months, respectively. In multivariate analyses, the Barcelona Clinic Liver Cancer, total bilirubin, vascular invasion, and NLR-PNI score adversely affected overall survival. In conclusion, the NLR-PNI score can improve the accuracy of prognoses for patients with unresectable HCC.

Indexed as

Nutrition AssessmentCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansLiver NeoplasmsLymphocyte CountLymphocytesMaleMiddle AgedMultivariate AnalysisNeoplasm StagingNeutrophilsPrognosisSurvival AnalysisTreatment Outcome

Identifiers

PMID29066730
PMCPMC5654965

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