ArticleScientific reports2017
Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025Review
- Rac1 GTPase activation impairs fear conditioning-induced structural changes in basolateral amygdala neurons and long-term fear memory formation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder.CNS neuroscience & therapeutics · 2022Article
- Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats.Frontiers in molecular neuroscience · 2022Article
- Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity.Frontiers in aging neuroscience · 2022Article
- Roles of palmitoylation in structural long-term synaptic plasticity.Molecular brain · 2021Review
- Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders.Frontiers in cell and developmental biology · 2021Review
- Rho GTPases in the Amygdala-A Switch for Fears?Cells · 2020Review
- TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory.Frontiers in synaptic neuroscience · 2020Review
- Silent synapses dictate cocaine memory destabilization and reconsolidation.Nature neuroscience · 2020Article
- Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory.Nature communications · 2019Article
- Engineering proteins for allosteric control by light or ligands.Nature protocols · 2019Article
- The Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory.Frontiers in molecular neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA). Rac GTPase and its downstream effector p21-activated kinase (PAK) are involved in such key neuronal functions. Here we show that optical activation of Rac1 GTPase using photoactivatable form of Rac1 (PA-Rac1) in amygdala led to phosphorylation of PAK and inhibition of long-term but not short-term auditory fear conditioning memory formation. Activation of PA-Rac1 in LA one day after fear conditioning had no effect on long-term fear memory tested 24 hrs after PA-Rac1 activation. Inhibition of PAK in LA by microinjection of the PAK inhibitor IPA-3 30 minutes before fear conditioning enhanced long-term but not short-term fear memory formation. Our results demonstrate that photoactivation of Rac1 GTPase in lateral amygdala impairs fear memory formation. Moreover, Rac1 effector PAK activity during fear conditioning constrains the formation of fear memory in LA. Thus, Rac GTPase and PAK proteins may serve as targets for treatment of fear and anxiety disorders.
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