ArticleNature communications2017
BCL-X
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
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- Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes.Nature nanotechnology · 2025Article
- A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.Journal of experimental & clinical cancer research : CR · 2025Review
- Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium.Science advances · 2025Article
- Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release.Cell death discovery · 2024Article
- Disarib, a Specific BCL2 Inhibitor, Induces Apoptosis in Triple-Negative Breast Cancer Cells and Impedes Tumour Progression in Xenografts by Altering Mitochondria-Associated Processes.International journal of molecular sciences · 2024Article
- An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release.Communications biology · 2024Article
- Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1.Oncology letters · 2024Article
- The role of alternative pre-mRNA splicing in cancer progression.Cancer cell international · 2023Review
- Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice.Nature communications · 2023Article
- Molecular Farming of Pembrolizumab and Nivolumab.International journal of molecular sciences · 2023Review
- Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.Biomolecules · 2022Review
- Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells.Molecules (Basel, Switzerland) · 2022Article
- SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances.Journal of experimental & clinical cancer research : CR · 2022Article
- Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death.Biomolecules · 2022Review
- A personalized molecular approach in multiple myeloma: the possible use of RAF/RAS/MEK/ERK and BCL-2 inhibitors.Exploration of targeted anti-tumor therapy · 2022Review
- Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation.Journal of experimental & clinical cancer research : CR · 2021Review
- IL-8, MSPa, MIF, FGF-9, ANG-2 and AgRP collection were identified for the diagnosis of colorectal cancer based on the support vector machine model.Cell cycle (Georgetown, Tex.) · 2021Article
- KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion.Journal of cellular and molecular medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Sophie de Carné TrécessonTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.ORCID http://orcid.org/0000-0002-9341-2586
Frédérique SouazéTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Agnès BassevilleTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Anne-Charlotte BernardTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Jessie PécotTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Jonathan LopezService de Biochimie et Biologie moléculaire-Centre Hospitalier Lyon Sud, Faculté de Médecine Lyon Sud-Université Lyon 1, Centre de Recherche en Cancérologie de Lyon-INSERM U1052 CNRS U5286, Lyon, 69003, France.ORCID http://orcid.org/0000-0003-3768-2378
Margaux BessouService de Biochimie et Biologie moléculaire-Centre Hospitalier Lyon Sud, Faculté de Médecine Lyon Sud-Université Lyon 1, Centre de Recherche en Cancérologie de Lyon-INSERM U1052 CNRS U5286, Lyon, 69003, France.
Kristopher A SarosiekDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Anthony LetaiDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Sophie Barillé-NionTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Isabelle ValoBiopathology Department, ICO - Centre de Lutte contre le Cancer Paul Papin, 15 rue André Boquel, Angers, France.
Olivier CoqueretTeam 12 'Targeted Therapies and Tumor Escape in Colorectal Cancer', CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - Centre de Lutte contre le Cancer Paul Papin, 15 rue André Boquel, Angers, 49055, France.
Catherine GuetteTeam 12 'Targeted Therapies and Tumor Escape in Colorectal Cancer', CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - Centre de Lutte contre le Cancer Paul Papin, 15 rue André Boquel, Angers, 49055, France.
Mario CamponeICO site René Gauducheau, Boulevard Jacques Monod, Saint Herblain, 44805, France.
Fabien GautierTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.
Philippe Paul JuinTeam 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France. philippe.juin@univ-nantes.fr.
Nantes Université · FRCentre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers · FRHarvard University · USInstitut Génétique Nantes Atlantique · FRUniversité catholique de l'ouest · FRUniversité Claude Bernard Lyon 1 · FRThe Francis Crick Institute · GB
Funding
Regulation of Apoptotic Priming and Competence in Healthy and Cancerous CellsR00CA188679 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI SAROSIEK, KRISTOPHER ANDREW · 2017 to 2019
$747kNCI NIH HHS R00 CA188679
Abstract
In tumours, accumulation of chemoresistant cells that express high levels of anti-apoptotic proteins such as BCL-X
Indexed as
Gene Expression Regulation, NeoplasticSignal TransductionAnimalsApoptosisbcl-X ProteinBreast NeoplasmsCell Line, TumorDrug Resistance, NeoplasmFemaleFos-Related Antigen 1HMGA2 ProteinHumansMass SpectrometryMCF-7 CellsMiceMice, NudeBCL2L1 protein, humanbcl-X ProteinFos-Related Antigen 1HMGA2 ProteinProto-Oncogene Proteins c-fosras Proteins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.