ArticleNature communications2017
Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Intravital single-molecule imaging reveals cytoskeletal turnover as a driver of membrane remodeling in live animals.bioRxiv : the preprint server for biology · 2026Article
- An active matter model captures spatial dynamics of actomyosin oscillations in larval epithelial cells duringProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effervescence in a binary mixture with nonlinear non-reciprocal interactions.Nature communications · 2025Article
- Spatial regulation of mitochondrial membrane potential by α5β1 integrin engagement in collective cell migration.Journal of cell science · 2025Article
- Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissues.iScience · 2023Review
- Pulsatile contractions and pattern formation in excitable actomyosin cortex.PLoS computational biology · 2022Article
- Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.eLife · 2021Article
- Cellular and Supracellular Planar Polarity: A Multiscale Cue to Elongate theFrontiers in cell and developmental biology · 2021Review
- Cell intercalation in a simple epithelium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- βH-spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination.EMBO reports · 2020Article
- Crystal-like order and defects in metazoan epithelia with spherical geometry.Scientific reports · 2020Article
- Scaling behaviour in steady-state contracting actomyosin networks.Nature physics · 2019Article
- Modulation of tissue growth heterogeneity by responses to mechanical stress.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Self-organized stress patterns drive state transitions in actin cortices.Science advances · 2018Article
- Mechanical and Systems Biology of Cancer.Computational and structural biotechnology journal · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue remodeling requires cell shape changes associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the hydrodynamics of actomyosin as a confined active elastomer with turnover of its components. Our treatment is adapted to describe the diversity of contractile dynamical regimes observed in vivo. When myosin-induced contractile stresses are low, the deformations of the active elastomer are affine and exhibit spontaneous oscillations, propagating waves, contractile collapse and spatiotemporal chaos. We study the nucleation, growth and coalescence of actomyosin-dense regions that, beyond a threshold, spontaneously move as a spatially localized traveling front. Large myosin-induced contractile stresses lead to nonaffine deformations due to enhanced actin and crosslinker turnover. This results in a transient actin network that is constantly remodeling and naturally accommodates intranetwork flows of the actomyosin-dense regions. We verify many predictions of our study in Drosophila embryonic epithelial cells undergoing neighbor exchange during germband extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.