Evidence map›Paper›PMID 29066618›Full record

ArticleThe Journal of biological chemistry2017

Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression.

Trevor Carden, Bhupendra Singh, Ved Mooga, Prachi Bajpai, Keshav K Singh

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 67 citations in OpenAlex.

  1. mtDNA copy number/BioImpacts : BI · 2025
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  12. Mitophagy-promoting miR-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Trevor CardenFrom the Departments of Genetics.
Bhupendra SinghFrom the Departments of Genetics.
Ved MoogaFrom the Departments of Genetics.
Prachi BajpaiFrom the Departments of Genetics.
Keshav K SinghFrom the Departments of Genetics, kksingh@uab.edu.
University of Alabama at Birmingham · US

Funding

Mitochondria in Prostate Cancer DiversityR01CA204430 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SINGH, KESHAV K · 2016 to 2020
$1.7M
Mechanisms of arsenic-induced carcinogenesisI01BX001716 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SINGH, KESHAV K · 2014 to 2017
–
BLRD VA I01 BX001716NCI NIH HHS R01 CA204430
6 · The paper itself

Abstract

The normal cellular function requires communication between mitochondria and the nucleus, termed mitochondria-to-nucleus retrograde signaling. Disruption of this mechanism has been implicated in the development of cancers. Many proteins are known modulators of retrograde signaling, but whether microRNAs (miRNAs) are also involved is unknown. We conducted an miRNA microarray analysis using RNA from a parental cell line, a Rho

Indexed as

Epigenesis, GeneticGene Expression Regulation, NeoplasticSignal TransductionAnimalsBreast NeoplasmsCell Line, TumorCell NucleusDNA, MitochondrialEnzyme InhibitorsFemaleGene DeletionGene Expression ProfilingHumansMice, NudeMicroRNAsMitochondriaDNA, MitochondrialEnzyme InhibitorsMicroRNAsMIRN663 microRNA, humanRNARNA, NeoplasmRNA, recombinantbreast cancerDNA methylationgene expressionmicroRNA (miRNA)miR-663mitochondriaOXPHOSretrograde signalingtumorigenesis

Identifiers

PMID29066618
PMCPMC5733605
OpenAlexW2766918003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.