Evidence map›Paper›PMID 29066577›Full record

ArticleThe Journal of experimental medicine2017

Identification and characterization of T reg-like cells in zebrafish.

Melissa Kasheta, Corrie A Painter, Finola E Moore, Riadh Lobbardi, Alysia Bryll, Eli Freiman, David Stachura, Arlin B Rogers, Yariv Houvras, David M Langenau and 1 more

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  8. Zebrafish: A Tractable Model for Analysis of T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Dietary Inclusion of Seabuckthorn (Frontiers in physiology · 2022
    Article
  18. Review
  19. Article
  20. Adenosine and Inflammation: Here, There and Everywhere.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melissa KashetaProgram in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.
Corrie A PainterProgram in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.
Finola E MooreMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA.
Riadh LobbardiMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA.
Alysia BryllProgram in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.
Eli FreimanProgram in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.ORCID http://orcid.org/0000-0002-6256-7120
David StachuraDepartment of Biological Sciences, California State University, Chico, CA.
Arlin B RogersDepartment of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA.
Yariv HouvrasDepartments of Surgery and Medicine, Weill Cornell Medical College, New York, NY.
David M LangenauMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA.ORCID http://orcid.org/0000-0001-6664-8318
Craig J CeolProgram in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA craig.ceol@umassmed.edu.ORCID http://orcid.org/0000-0002-7188-7580

Funding

Immune Compromises Zebrafish for Cell TransplantationR24OD016761 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI LANGENAU, DAVID MICHAEL · 2013 to 2021
$5.2M
Use of comparative genomics to identify novel regulators of melanoma progressionR01AR063850 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CEOL, CRAIG JOSEPH · 2013 to 2017
$1.8M
NIAMS NIH HHS R01 AR063850NIH HHS R24 OD016761
6 · The paper itself

Abstract

Regulatory T (T reg) cells are a specialized sublineage of T lymphocytes that suppress autoreactive T cells. Functional studies of T reg cells in vitro have defined multiple suppression mechanisms, and studies of T reg-deficient humans and mice have made clear the important role that these cells play in preventing autoimmunity. However, many questions remain about how T reg cells act in vivo. Specifically, it is not clear which suppression mechanisms are most important, where T reg cells act, and how they get there. To begin to address these issues, we sought to identify T reg cells in zebrafish, a model system that provides unparalleled advantages in live-cell imaging and high-throughput genetic analyses. Using a

Indexed as

AnimalsBase SequenceChronic DiseaseGene Expression RegulationGenes, ReporterGreen Fluorescent ProteinsHematopoiesisInflammationLymphocytesMutationPhylogenySplenomegalySurvival AnalysisThymocytesT-Lymphocytes, RegulatoryZebrafishenhanced green fluorescent proteinGreen Fluorescent ProteinsZebrafish Proteins

Identifiers

PMID29066577
PMCPMC5716030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.