Evidence map›Paper›PMID 29066559›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation.

Thomas Effertz, Lars Becker, Anthony W Peng, Anthony J Ricci

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 68 citations in OpenAlex.

  1. CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. PIPbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Ectopic mouse TMC1 and TMC2 alone form mechanosensitive channels that are potently modulated by TMIE.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Review
  16. Article
  17. The Effect of aCells · 2022
    Article
  18. Article
  19. Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022
    Review
  20. Identifying targets to prevent aminoglycoside ototoxicity.Molecular and cellular neurosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thomas EffertzDepartment of Otolaryngology, Head & Neck Surgery, and.ORCID 0000-0002-4993-7887
Lars BeckerDepartment of Otolaryngology, Head & Neck Surgery, and.ORCID 0000-0002-3041-3362
Anthony W PengDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.ORCID 0000-0002-2208-6779
Anthony J RicciDepartment of Otolaryngology, Head & Neck Surgery, and aricci@stanford.edu.ORCID 0000-0002-1706-8904
Emory University Hospital · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Tonotopic variations in mechano-electric transductionR01DC003896 · NIDCD · STANFORD UNIVERSITY · PI RICCI, ANTHONY J · 1999 to 2022
$11.1M
Molecular roles in active and passive mechanics in cochlear hair bundlesR00DC013299 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI PENG, ANTHONY WEI · 2015 to 2017
$747k
NIDCD NIH HHS R00 DC013299NIDCD NIH HHS R01 DC003896
6 · The paper itself

Abstract

Membrane proteins, such as ion channels, interact dynamically with their lipid environment. Phosphoinositol-4,5-bisphosphate (PIP

Indexed as

Adaptation, PhysiologicalAnimalsFemaleHair Cells, AuditoryMaleMechanotransduction, CellularPhosphatidylinositol 4,5-DiphosphateRatsRats, Sprague-DawleyPhosphatidylinositol 4,5-Diphosphateadaptationcell membranehair cellmechanotransductionPIP2

Identifiers

PMID29066559
PMCPMC5707765
OpenAlexW2766931381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.