Evidence map›Paper›PMID 29066557›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus.

Yingtang Shi, Ruth L Stornetta, Daniel S Stornetta, Suna Onengut-Gumuscu, Emily A Farber, Stephen D Turner, Patrice G Guyenet, Douglas A Bayliss

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Functional modulation of retrotrapezoid neurons drives fentanyl-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  14. Review
  15. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
    Review
  16. Review
  17. Interactions between Arousal State and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  18. Review
  19. Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  20. Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yingtang ShiDepartment of Pharmacology.
Ruth L StornettaDepartment of Pharmacology, rs3j@virginia.edu.ORCID 0000-0001-7278-8923
Daniel S StornettaDepartment of Pharmacology.
Suna Onengut-GumuscuCenter for Public Health Genomics.ORCID 0000-0002-6563-8334
Emily A FarberCenter for Public Health Genomics.
Stephen D TurnerDepartment of Public Health Sciences, and.ORCID 0000-0001-9140-9028
Patrice G GuyenetDepartment of Pharmacology.ORCID 0000-0003-1739-2306
Douglas A BaylissDepartment of Pharmacology.ORCID 0000-0002-5630-2572
Institute of Pharmacology · CZOffice of Public Health Genomics · USFaculty of Public Health · GBVirginia College · US

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Cellular/Molecular Mechanisms of Respiratory Neuronal ChemosensitivityR01HL108609 · NHLBI · UNIVERSITY OF VIRGINIA · PI Douglas A. Bayliss · 2011 to 2026
$6.5M
NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL108609
6 · The paper itself

Abstract

The retrotrapezoid nucleus (RTN) consists, by definition, of Phox2b-expressing, glutamatergic, non-catecholaminergic, noncholinergic neurons located in the parafacial region of the medulla oblongata. An unknown proportion of RTN neurons are central respiratory chemoreceptors and there is mounting evidence for biochemical diversity among these cells. Here, we used multiplexed

Indexed as

AnimalsFemaleGene ExpressionHypoxiaMaleMedulla OblongataMiceMice, Inbred C57BLMice, TransgenicNeurokinin BNeuronsOrgan Culture TechniquesRatsRats, Sprague-DawleyNeurokinin Bneuromedin Bcentral chemoreceptorsGpr4hypercapniamedulla oblongataNeuromedin BTASK-2

Identifiers

PMID29066557
PMCPMC5707768
OpenAlexW2766218520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.