ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Cortical Regulation of Nociception of the Trigeminal Nucleus Caudalis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Organization and development of bilateral somatosensory feedback projections in mice.iScience · 2025Article
- Transcutaneous occipital nerve stimulation alleviated migraine related pain by regulating synaptic plasticity and CGRP expression in the periaqueductal gray of male rats.The journal of headache and pain · 2025Article
- Emerging Psychotropic Drug for the Treatment of Trigeminal Pain: Salvinorin A.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Inflammation, brain connectivity, and neuromodulation in post-traumatic headache.Brain, behavior, & immunity - health · 2024Review
- Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex.Nature communications · 2022Article
- Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics.Neuroscience bulletin · 2022Review
- Xiongshao Zhitong Recipe Attenuates Nitroglycerin-Induced Migraine-Like BehaviorsFrontiers in pharmacology · 2022Article
- NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain.Frontiers in cellular neuroscience · 2022Review
- G protein-coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain.CNS neuroscience & therapeutics · 2021Article
- Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.Scientific reports · 2020Article
- An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain.Medicines (Basel, Switzerland) · 2019Review
- Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy.Frontiers in neurology · 2018Article
- Age-Dependent Anti-migraine Effects of Valproic Acid and Topiramate in Rats.Frontiers in pharmacology · 2018Article
- Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Pain perception is strongly influenced by descending pathways from "higher" brain centers that regulate the activity of spinal circuits. In addition to the extensively studied descending system originating from the medulla, the neocortex provides dense anatomical projections that directly target neurons in the spinal cord and the spinal trigeminal nucleus caudalis (SpVc). Evidence exists that these corticotrigeminal pathways may modulate the processing of nociceptive inputs by SpVc, and regulate pain perception. We demonstrate here, with anatomical and optogenetic methods, and using both rats and mice (of both sexes), that corticotrigeminal axons densely innervate SpVc, where they target and directly activate inhibitory and excitatory neurons. Electrophysiological recordings reveal that stimulation of primary somatosensory cortex potently suppresses SpVc responses to noxious stimuli and produces behavioral hypoalgesia. These findings demonstrate that the corticotrigeminal pathway is a potent modulator of nociception and a potential target for interventions to alleviate chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.