Evidence map›Paper›PMID 29066552›Full record

ArticlemBio2017

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in

Giuseppe Ianiri, Shelly Applen Clancey, Soo Chan Lee, Joseph Heitman

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Journal of fungi (Basel, Switzerland) · 2021
    Article
  5. HGT in the human and skin commensalProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Article
  7. Approaches for Genetic Discoveries in the Skin Commensal and PathogenicFrontiers in cellular and infection microbiology · 2020
    Review
  8. Article
  9. Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites.Drug metabolism and disposition: the biological fate of chemicals · 2019
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Giuseppe IaniriDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Shelly Applen ClanceyDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Soo Chan LeeDepartment of Biology, South Texas Center for Emerging Infectious Diseases (STCEID), The University of Texas at San Antonio, San Antonio, Texas, USA.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA heitm001@duke.edu.
Duke University Hospital · USDuke University · USTexas Center for Infectious Disease · US

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

The genus

Indexed as

AnimalsAntifungal AgentsCalcineurin InhibitorsDermatomycosesFungal ProteinsHumansImmunosuppressive AgentsMalasseziaModels, MolecularSignal TransductionTacrolimusTacrolimus Binding Protein 1AAntifungal AgentsCalcineurin InhibitorsFungal ProteinsImmunosuppressive AgentspimecrolimusTacrolimusTacrolimus Binding Protein 1Acalcineurin inhibitorsFKBP12-binding proteinhypermutatorMalassezia

Identifiers

PMID29066552
PMCPMC5654937
OpenAlexW2766409943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.