Evidence map›Paper›PMID 29066549›Full record

ArticlemBio2017

Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in

Brett M Babin, Lydia Atangcho, Mark B van Eldijk, Michael J Sweredoski, Annie Moradian, Sonja Hess, Tim Tolker-Nielsen, Dianne K Newman, David A Tirrell

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Global analysis of protein degradation reveals instability of diverse regulators inProceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Article
  8. Review
  9. Strategies for combating antibiotic resistance in bacterial biofilms.Frontiers in cellular and infection microbiology · 2024
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Brett M BabinDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.ORCID 0000-0002-4133-6665
Lydia AtangchoDepartment of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Mark B van EldijkDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Michael J SweredoskiProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, California, USA.
Annie MoradianProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, California, USA.
Sonja HessProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, California, USA.
Tim Tolker-NielsenCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-9751-474X
Dianne K NewmanDivision of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California, USA dkn@caltech.edu tirrell@caltech.edu.
David A TirrellDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA dkn@caltech.edu tirrell@caltech.edu.
California Institute of Technology · USUniversity of Copenhagen · DKUniversity of Michigan · US

Funding

Geobiological approaches to understanding pulmonary infections in situR01HL117328 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NEWMAN, DIANNE K · 2012 to 2016
$2.1M
Purchase of a Liquid Chromatograph-Orbitrap VELOS mass spectrometerS10RR029594 · NCRR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HESS, SONJA · 2011 to 2011
$600k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR029594NHLBI NIH HHS R01 HL117328
6 · The paper itself

Abstract

Biofilm infections exhibit high tolerance against antibiotic treatment. The study of biofilms is complicated by phenotypic heterogeneity; biofilm subpopulations differ in their metabolic activities and their responses to antibiotics. Here, we describe the use of the bio-orthogonal noncanonical amino acid tagging (BONCAT) method to enable selective proteomic analysis of a

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBiofilmsDrug Resistance, BacterialProteomeProteomicsPseudomonas aeruginosaAnti-Bacterial AgentsBacterial ProteinsProteomeantibiotic resistancebiofilmsBONCATproteomicsPseudomonas aeruginosa

Identifiers

PMID29066549
PMCPMC5654934
OpenAlexW2766203511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.